EPO_BOVIN
ID EPO_BOVIN Reviewed; 192 AA.
AC P48617; A3FFT0;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Erythropoietin;
DE Flags: Precursor;
GN Name=EPO;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Boran; TISSUE=Kidney;
RX PubMed=8666286; DOI=10.1016/0378-1119(95)00895-0;
RA Suliman H.B., Majiwa P.A.O., Feldman B.F., Mertens B., Logan-Henfrey L.L.;
RT "Cloning of a cDNA encoding bovine erythropoietin and analysis of its
RT transcription in selected tissues.";
RL Gene 171:275-280(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Jin S., Zhong J.C., Chen Z.H., Ma Z.J.;
RT "Cloning and sequence analysis on erythropoietin (EPO) gene of Bos taurus
RT (San Jiang yellow cattle).";
RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Hormone involved in the regulation of erythrocyte
CC proliferation and differentiation and the maintenance of a
CC physiological level of circulating erythrocyte mass. Binds to EPOR
CC leading to EPOR dimerization and JAK2 activation thereby activating
CC specific downstream effectors, including STAT1 and STAT3.
CC {ECO:0000250|UniProtKB:P01588}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Produced by kidney or liver of adult mammals and by
CC liver of fetal or neonatal mammals.
CC -!- SIMILARITY: Belongs to the EPO/TPO family. {ECO:0000305}.
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DR EMBL; L41354; AAB41268.1; -; mRNA.
DR EMBL; U44762; AAA86653.1; -; mRNA.
DR EMBL; EF374049; ABN48309.1; -; Genomic_DNA.
DR RefSeq; NP_776334.1; NM_173909.2.
DR AlphaFoldDB; P48617; -.
DR SMR; P48617; -.
DR STRING; 9913.ENSBTAP00000004450; -.
DR PaxDb; P48617; -.
DR PRIDE; P48617; -.
DR Ensembl; ENSBTAT00000072093; ENSBTAP00000072843; ENSBTAG00000003430.
DR GeneID; 280784; -.
DR KEGG; bta:280784; -.
DR CTD; 2056; -.
DR VEuPathDB; HostDB:ENSBTAG00000003430; -.
DR VGNC; VGNC:28549; EPO.
DR eggNOG; ENOG502RXRC; Eukaryota.
DR GeneTree; ENSGT00390000017226; -.
DR HOGENOM; CLU_110946_0_0_1; -.
DR InParanoid; P48617; -.
DR OMA; GVRECPA; -.
DR OrthoDB; 1175751at2759; -.
DR TreeFam; TF333413; -.
DR Proteomes; UP000009136; Chromosome 25.
DR Bgee; ENSBTAG00000003430; Expressed in cumulus cell and 11 other tissues.
DR ExpressionAtlas; P48617; baseline and differential.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005128; F:erythropoietin receptor binding; ISS:UniProtKB.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR GO; GO:0071474; P:cellular hyperosmotic response; IEA:Ensembl.
DR GO; GO:0007566; P:embryo implantation; IEA:Ensembl.
DR GO; GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.
DR GO; GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-KW.
DR GO; GO:0038162; P:erythropoietin-mediated signaling pathway; ISS:UniProtKB.
DR GO; GO:0042541; P:hemoglobin biosynthetic process; IEA:Ensembl.
DR GO; GO:0033028; P:myeloid cell apoptotic process; IEA:Ensembl.
DR GO; GO:0010523; P:negative regulation of calcium ion transport into cytosol; IEA:Ensembl.
DR GO; GO:2001258; P:negative regulation of cation channel activity; IEA:Ensembl.
DR GO; GO:1902251; P:negative regulation of erythrocyte apoptotic process; IEA:Ensembl.
DR GO; GO:1902219; P:negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR019767; EPO/TPO_CS.
DR InterPro; IPR001323; EPO_TPO.
DR InterPro; IPR003013; Erythroptn.
DR PANTHER; PTHR10370; PTHR10370; 1.
DR Pfam; PF00758; EPO_TPO; 1.
DR PIRSF; PIRSF001951; EPO; 1.
DR PRINTS; PR00272; ERYTHROPTN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00817; EPO_TPO; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Erythrocyte maturation; Glycoprotein; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..192
FT /note="Erythropoietin"
FT /id="PRO_0000008397"
FT CARBOHYD 49
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 108
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 32..187
FT /evidence="ECO:0000250"
FT DISULFID 54..58
FT /evidence="ECO:0000250"
SQ SEQUENCE 192 AA; 21076 MW; DBC419022F7B483A CRC64;
MGARDCTPLL MLSFLLFPLG FPVLGAPARL ICDSRVLERY ILEAREAENA TMGCAEGCSF
NENITVPDTK VNFYAWKRME VQQQALEVWQ GLALLSEAIL RGQALLANAS QPCEALRLHV
DKAVSGLRSL TSLLRALGAQ KEAISLPDAT PSAAPLRAFT VDALSKLFRI YSNFLRGKLT
LYTGEACRRG DR
