ID   EPO_EPICO               Reviewed;         185 AA.
AC   Q5IGQ0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Erythropoietin;
DE   Flags: Precursor;
GN   Name=epo;
OS   Epinephelus coioides (Orange-spotted grouper) (Epinephelus nebulosus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Serranoidei; Serranidae; Epinephelinae;
OC   Epinephelini; Epinephelus.
OX   NCBI_TaxID=94232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Yu R.M.K., Wu R.S.S., Lam G.K.W., Kong R.Y.C.;
RT   "The molecular responses of marine fish to both oxygen deprivation and
RT   xenobiotic exposure.";
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Erythropoietin is the principal hormone involved in the
CC       regulation of erythrocyte differentiation and the maintenance of a
CC       physiological level of circulating erythrocyte mass. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EPO/TPO family. {ECO:0000305}.
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DR   EMBL; AY735012; AAW29029.1; -; mRNA.
DR   AlphaFoldDB; Q5IGQ0; -.
DR   SMR; Q5IGQ0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005128; F:erythropoietin receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001323; EPO_TPO.
DR   InterPro; IPR003013; Erythroptn.
DR   PANTHER; PTHR10370; PTHR10370; 1.
DR   Pfam; PF00758; EPO_TPO; 1.
DR   PIRSF; PIRSF001951; EPO; 1.
DR   PRINTS; PR00272; ERYTHROPTN.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Erythrocyte maturation; Hormone; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..185
FT                   /note="Erythropoietin"
FT                   /id="PRO_0000313666"
FT   DISULFID        32..180
FT                   /evidence="ECO:0000250"
FT   DISULFID        54..58
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   185 AA;  20721 MW;  1C1F4D027EB5FE61 CRC64;
     MLQKRGRGLL VLLLMLLEWT RPGLLSPLRP ICDLRVLNHF IKEARDAEVA MKSCTEGCSL
     SESVTVPQTR VDFDVWEKKN GLEQAQEVQS GLWLLQQALN LLRTSVTNTA LHSHIDNSIR
     NLLSINAVLR SLNIQEYTPP ASTVALEGTW RVSSATDLLQ VHVNFLRGKV RLLLLDAQAC
     QQDVS