ID   EPO_RABIT               Reviewed;         195 AA.
AC   Q9GKA2; Q9GKA3;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 2.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Erythropoietin;
DE   Flags: Precursor;
GN   Name=EPO;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=New Zealand white; TISSUE=Kidney;
RX   PubMed=11396976; DOI=10.1006/bbrc.2001.5028;
RA   Vilalta A., Wu D., Margalith M., Hobart P.;
RT   "Rabbit EPO gene and cDNA: expression of rabbit EPO after intramuscular
RT   injection of pDNA.";
RL   Biochem. Biophys. Res. Commun. 284:823-827(2001).
CC   -!- FUNCTION: Hormone involved in the regulation of erythrocyte
CC       proliferation and differentiation and the maintenance of a
CC       physiological level of circulating erythrocyte mass. Binds to EPOR
CC       leading to EPOR dimerization and JAK2 activation thereby activating
CC       specific downstream effectors, including STAT1 and STAT3.
CC       {ECO:0000250|UniProtKB:P01588}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the EPO/TPO family. {ECO:0000305}.
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DR   EMBL; AF290943; AAG36961.1; -; mRNA.
DR   EMBL; AF290944; AAG36962.1; -; Genomic_DNA.
DR   PIR; JC7699; JC7699.
DR   RefSeq; NP_001075559.1; NM_001082090.1.
DR   AlphaFoldDB; Q9GKA2; -.
DR   SMR; Q9GKA2; -.
DR   STRING; 9986.ENSOCUP00000004681; -.
DR   GeneID; 100008786; -.
DR   KEGG; ocu:100008786; -.
DR   CTD; 2056; -.
DR   eggNOG; ENOG502RXRC; Eukaryota.
DR   InParanoid; Q9GKA2; -.
DR   OrthoDB; 1175751at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005128; F:erythropoietin receptor binding; ISS:UniProtKB.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.
DR   GO; GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-KW.
DR   GO; GO:0038162; P:erythropoietin-mediated signaling pathway; ISS:UniProtKB.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR019767; EPO/TPO_CS.
DR   InterPro; IPR001323; EPO_TPO.
DR   InterPro; IPR003013; Erythroptn.
DR   PANTHER; PTHR10370; PTHR10370; 1.
DR   Pfam; PF00758; EPO_TPO; 1.
DR   PIRSF; PIRSF001951; EPO; 1.
DR   PRINTS; PR00272; ERYTHROPTN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00817; EPO_TPO; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Erythrocyte maturation; Glycoprotein; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..195
FT                   /note="Erythropoietin"
FT                   /id="PRO_0000008407"
FT   CARBOHYD        52
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        66
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        111
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        35..190
FT                   /evidence="ECO:0000250"
FT   DISULFID        57..61
FT                   /evidence="ECO:0000250"
FT   CONFLICT        3
FT                   /note="V -> A (in Ref. 1; AAG36962)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   195 AA;  21054 MW;  0999DA7D852713F3 CRC64;
     MGVRGRLALL PLALLCLLVL ALGLPVLGAP ARLICDSRVL ERYILEAKEA ENVTMGCAEG
     CSLGENITVP DTKVNFHHWK KSEAGRHAVE VWQGLALLSE AMLRSQALLA NSSQLPETLQ
     VHVDKAVSGL RSLTSLLRAL GVQKEAVSPP EAASSAAPLR TVAADTLCKL FRIYSNFLRG
     KLKLYTGEAC RRGDR