AGO3_ORYSJ
ID AGO3_ORYSJ Reviewed; 1109 AA.
AC Q7XTS3; Q0JA51;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Protein argonaute 3;
DE Short=OsAGO3;
GN Name=AGO3; OrderedLocusNames=Os04g0615800, LOC_Os04g52550;
GN ORFNames=OSJNBa0008M17.12;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12447439; DOI=10.1038/nature01183;
RA Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y.,
RA Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q.,
RA Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T.,
RA Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R.,
RA Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G.,
RA Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C.,
RA Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J.,
RA Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J.,
RA Li J., Hong G., Xue Y., Han B.;
RT "Sequence and analysis of rice chromosome 4.";
RL Nature 420:316-320(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 587-1109.
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18826656; DOI=10.1186/1471-2164-9-451;
RA Kapoor M., Arora R., Lama T., Nijhawan A., Khurana J.P., Tyagi A.K.,
RA Kapoor S.;
RT "Genome-wide identification, organization and phylogenetic analysis of
RT dicer-like, argonaute and RNA-dependent RNA polymerase gene families and
RT their expression analysis during reproductive development and stress in
RT rice.";
RL BMC Genomics 9:451-451(2008).
CC -!- FUNCTION: Probably involved in the RNA silencing pathway. May bind to
CC short RNAs such as microRNAs (miRNAs) or short interfering RNAs
CC (siRNAs), and represses the translation of mRNAs which are
CC complementary to them (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the argonaute family. Ago subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAF15786.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL662950; CAD41796.2; -; Genomic_DNA.
DR EMBL; AP008210; BAF15786.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK107521; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; Q7XTS3; -.
DR SMR; Q7XTS3; -.
DR STRING; 4530.OS04T0615800-01; -.
DR PaxDb; Q7XTS3; -.
DR PRIDE; Q7XTS3; -.
DR eggNOG; KOG1041; Eukaryota.
DR HOGENOM; CLU_004544_6_2_1; -.
DR InParanoid; Q7XTS3; -.
DR Proteomes; UP000000763; Chromosome 4.
DR Proteomes; UP000059680; Chromosome 4.
DR Genevisible; Q7XTS3; OS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004521; F:endoribonuclease activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0035194; P:post-transcriptional gene silencing by RNA; IBA:GO_Central.
DR CDD; cd04657; Piwi_ago-like; 1.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR014811; ArgoL1.
DR InterPro; IPR032474; Argonaute_N.
DR InterPro; IPR003100; PAZ_dom.
DR InterPro; IPR036085; PAZ_dom_sf.
DR InterPro; IPR003165; Piwi.
DR InterPro; IPR045246; Piwi_ago-like.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR Pfam; PF08699; ArgoL1; 1.
DR Pfam; PF16486; ArgoN; 1.
DR Pfam; PF02170; PAZ; 1.
DR Pfam; PF02171; Piwi; 1.
DR SMART; SM01163; DUF1785; 1.
DR SMART; SM00950; Piwi; 1.
DR SUPFAM; SSF101690; SSF101690; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
DR PROSITE; PS50821; PAZ; 1.
DR PROSITE; PS50822; PIWI; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; RNA-mediated gene silencing.
FT CHAIN 1..1109
FT /note="Protein argonaute 3"
FT /id="PRO_0000378430"
FT DOMAIN 410..521
FT /note="PAZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00142"
FT DOMAIN 720..1023
FT /note="Piwi"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00150"
FT REGION 1..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..165
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 825
FT /note="S -> C (in Ref. 5; AK107521)"
FT /evidence="ECO:0000305"
FT CONFLICT 1096
FT /note="P -> A (in Ref. 5; AK107521)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1109 AA; 122753 MW; 96CCB838CA4B9219 CRC64;
MAGRGGRDPR RGYDGGYGYP RGGGGQGGTN RGRDGQRGGG RNGPRGGRFP GGRGVEPRRG
GDVLGGGQGG GRGTTAGAGG LVRGGSELAV GAELRRRVPT CHVNDFPELG IGGTPVLVRR
WRPRDHRDQH DHQSQRHHHR HHHHQRQRHH HHHQRQQRRG SRTRDPRVRR GPLRIPYGED
EKEEPPATPI ASSNKNKREE PPTKHRPMAR PPGGGGPLSK GEVKLLVNHF SVDYPKESTF
FHYEIRIKLG DGPNRKLSKA ELLTVKNELF EHESLQELSS AVAYDGERNL YTCAELPEDC
IVPVSKFRVK DSSRTYIVSV KLKKPLPLSQ LLEQRPGPRD VMQGLDVIVR EASSFGKIVL
GQGFYPQSGS EAISDSNIVA LKGTQQSLKC TQKGLILCVD YSVLPCWKAG SVLDLVKTMK
FMEYPLLEDQ LKKLNNALKG LCVTVSHRKT EEKYTVKGLT DKPADQITFK DSKSGQTTKL
IEYYKETYKK EIEHPMLPCL DLSKSKSKQN YVPIEFCNIP EGERYPVARL DDKKSDNKGE
QEKPSTKTTL RKISIKVASS RKEEILDLVG NAQDGPCRGK IAQRFRISLD AAMMEVTGRI
LAPPTLELGT GTSRGQTFKF TIHQDDCQWN WKLKKYDKRV VAHGGTLNCW GVVDFSEGDL
ESKFIDKVVR KCSALGMVMT RKPCYEHVSN MEVLSDPKSL RDALIEAKRA AEEEDKKLQL
LFCPMLNRCH GYKTLKLMCE TELGIQTQCF LSTAAKLDEK RQDQYITNLA LKINGKIGGS
NMQLDPDSIP VVSAKDFMFI GADVNHPPPG NVSKDIPSIA AVVASVDKGA SKYVTRIRAQ
YHRCEMIQNL GDICKELIGA YEKVNKKKPD SIIYFRDGVS DGQFDMVLNE ELADMENKIM
VGDYPKITVI VAKKRHHTRL FPKDRNQRQT KNGNVLPGTV VDTDVVDPTA YDFYLCSHKG
EVGTSRPTHY YSLLDEHGFA SDDLQKLVYN LCFVFARCTK PVSLATPVYY ADLAAYRGRL
YYEGMMMLQP AASAASASEA MMPAAQPQAA AAAAAAASPS SSAASSSEGM TASQPQAPAA
EAASSSAGAA DFRELPPMHG DLLNNMFFL
