ID   EPO_TETNG               Reviewed;         180 AA.
AC   Q4T554; Q6UAM1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Erythropoietin;
DE   Flags: Precursor;
GN   Name=epo; ORFNames=GSTENG00006991001;
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Lutfalla G.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
CC   -!- FUNCTION: Erythropoietin is the principal hormone involved in the
CC       regulation of erythrocyte differentiation and the maintenance of a
CC       physiological level of circulating erythrocyte mass. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EPO/TPO family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAR25698.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY374507; AAR25698.1; ALT_INIT; mRNA.
DR   EMBL; CAAE01009425; CAF91978.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q4T554; -.
DR   SMR; Q4T554; -.
DR   STRING; 99883.ENSTNIP00000004178; -.
DR   KEGG; tng:GSTEN00006991G001; -.
DR   InParanoid; Q4T554; -.
DR   TreeFam; TF333413; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005128; F:erythropoietin receptor binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001323; EPO_TPO.
DR   InterPro; IPR003013; Erythroptn.
DR   PANTHER; PTHR10370; PTHR10370; 1.
DR   Pfam; PF00758; EPO_TPO; 1.
DR   PIRSF; PIRSF001951; EPO; 1.
DR   PRINTS; PR00272; ERYTHROPTN.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Erythrocyte maturation; Glycoprotein; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..180
FT                   /note="Erythropoietin"
FT                   /id="PRO_0000313668"
FT   CARBOHYD        75
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        27..175
FT                   /evidence="ECO:0000250"
FT   DISULFID        49..53
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   180 AA;  19948 MW;  7FB251FCC54BD48F CRC64;
     MTGLLAFLLI VLEWTRPSLP SPLRPICDLR VLNHFIKEAQ DAEAAMKTCR EGCTLSESVV
     VPQTTVDFDV WEKKNASAKA EEVQSGLWLL QQAFNFLRTS VTNAALHSHI DNAVRNLLSV
     NAVLRSLNIQ EFTPQANGAE IEGTWRASSA AELLQVYVNF LRGKARLLLL DAQACQQDVS