AGO4A_ORYSJ
ID AGO4A_ORYSJ Reviewed; 904 AA.
AC Q9SDG8; A0A0P0V0X4;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Protein argonaute 4A;
DE Short=OsAGO4a;
GN Name=AGO4A; OrderedLocusNames=Os01g0275600, LOC_Os01g16870;
GN ORFNames=P0038F12.13;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12447438; DOI=10.1038/nature01184;
RA Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT "The genome sequence and structure of rice chromosome 1.";
RL Nature 420:312-316(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18826656; DOI=10.1186/1471-2164-9-451;
RA Kapoor M., Arora R., Lama T., Nijhawan A., Khurana J.P., Tyagi A.K.,
RA Kapoor S.;
RT "Genome-wide identification, organization and phylogenetic analysis of
RT dicer-like, argonaute and RNA-dependent RNA polymerase gene families and
RT their expression analysis during reproductive development and stress in
RT rice.";
RL BMC Genomics 9:451-451(2008).
CC -!- FUNCTION: Probably involved in the RNA silencing pathway. May bind to
CC short RNAs such as microRNAs (miRNAs) or short interfering RNAs
CC (siRNAs), and represses the translation of mRNAs which are
CC complementary to them (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the argonaute family. Ago subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AK064813; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AP000836; BAA88176.1; -; Genomic_DNA.
DR EMBL; AP008207; BAF04636.1; -; Genomic_DNA.
DR EMBL; AP014957; BAS71541.1; -; Genomic_DNA.
DR EMBL; AK064813; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015621073.1; XM_015765587.1.
DR RefSeq; XP_015621074.1; XM_015765588.1.
DR AlphaFoldDB; Q9SDG8; -.
DR SMR; Q9SDG8; -.
DR STRING; 4530.OS01T0275600-01; -.
DR iPTMnet; Q9SDG8; -.
DR PaxDb; Q9SDG8; -.
DR PRIDE; Q9SDG8; -.
DR EnsemblPlants; Os01t0275600-01; Os01t0275600-01; Os01g0275600.
DR GeneID; 4324438; -.
DR Gramene; Os01t0275600-01; Os01t0275600-01; Os01g0275600.
DR KEGG; osa:4324438; -.
DR eggNOG; KOG1041; Eukaryota.
DR HOGENOM; CLU_004544_2_0_1; -.
DR InParanoid; Q9SDG8; -.
DR OMA; PTNQEYK; -.
DR OrthoDB; 159407at2759; -.
DR Proteomes; UP000000763; Chromosome 1.
DR Proteomes; UP000059680; Chromosome 1.
DR ExpressionAtlas; Q9SDG8; baseline and differential.
DR Genevisible; Q9SDG8; OS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004521; F:endoribonuclease activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0035194; P:post-transcriptional gene silencing by RNA; IBA:GO_Central.
DR CDD; cd04657; Piwi_ago-like; 1.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR014811; ArgoL1.
DR InterPro; IPR032472; ArgoL2.
DR InterPro; IPR032474; Argonaute_N.
DR InterPro; IPR003100; PAZ_dom.
DR InterPro; IPR036085; PAZ_dom_sf.
DR InterPro; IPR003165; Piwi.
DR InterPro; IPR045246; Piwi_ago-like.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR Pfam; PF08699; ArgoL1; 1.
DR Pfam; PF16488; ArgoL2; 1.
DR Pfam; PF16486; ArgoN; 1.
DR Pfam; PF02170; PAZ; 1.
DR Pfam; PF02171; Piwi; 1.
DR SMART; SM01163; DUF1785; 1.
DR SMART; SM00950; Piwi; 1.
DR SUPFAM; SSF101690; SSF101690; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
DR PROSITE; PS50821; PAZ; 1.
DR PROSITE; PS50822; PIWI; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; RNA-mediated gene silencing.
FT CHAIN 1..904
FT /note="Protein argonaute 4A"
FT /id="PRO_0000378431"
FT DOMAIN 268..388
FT /note="PAZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00142"
FT DOMAIN 557..865
FT /note="Piwi"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00150"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 871..890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 300
FT /note="L -> P (in Ref. 5; AK064813)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 904 AA; 100639 MW; BAEB650CCA79E2E4 CRC64;
MESNSGEIEE LPPPPPLPPN AEPIKTDDTK KLSKPKRALM ARSGCGKKGQ PIQLLTNHFK
VSLKAADEFF HHYYVNLKYE DDRPVDGKGI GRKVLDKLQQ TYASELANKD FAYDGEKSLF
TIGALPQVNN EFTVVLEDFN TGKSSANGGS PGNDSPGNDR KRVRRPYQTK TFKVELNFAA
KIPMSAIAQA LRGQESENTQ EAIRVIDIIL RQHSAKQGCL LVRQSFFHNN PSNFVDLGGG
VMGCRGFHSS FRATQSGLSL NIDVSTTMIV KPGPVVDFLL ANQKVDHPNK IDWAKAKRAL
KNLRIKTSPA NTEYKIVGLS ERNCYEQMFT LKQRNGDGEP EGVEVSVYEY FVKNRGIELR
YSGDFPCINV GKPKRPTYFP IELCSLVPLQ RYTKALSTLQ RSSLVEKSRQ KPEERMSVLS
DVLKRSNYDS EPMLNSCGIS IARGFTQVAG RVLQAPKLKA GNGEDLFARN GRWNFNNKRL
IKASSIEKWA VVNFSARCNI RDLVRDIIKC GGMKGIKVED PFDVIEEDPS MRRAPAARRV
DGMIDKMQKK LPGQPKFLLC VLAERKNSDI YGPWKRKCLA EFGIITQCVA PTRVNDQYIT
NVLLKINAKL GGLNSLLQIE TSPSIPLVSK VPTIILGMDV SHGSPGQSDI PSIAAVVSSR
EWPLVSKYRA SVRSQSPKLE MIDGLFKPQG AQEDDGLIRE LLVDFYTSTG KRKPDQVIIF
RDGVSESQFT QVLNIELDQI IEACKFLDEN WSPKFTLIVA QKNHHTKFFV PGSQNNVPPG
TVVDNAVCHP RNNDFYMCAH AGMIGTTRPT HYHILHDEIG FSADDLQELV HSLSYVYQRS
TTAISVVAPI CYAHLAAAQV SQFIKFDEMS ETSSSHGGHT SAGSAPVPEL PRLHNKVRSS
MFFC
