EPS15_DICDI
ID EPS15_DICDI Reviewed; 1196 AA.
AC Q54KI4;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Epidermal growth factor receptor substrate 15 homolog;
GN Name=eps15; ORFNames=DDB_G0287325;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP INTERACTION WITH TOM1.
RX PubMed=19054384; DOI=10.1111/j.1600-0854.2008.00855.x;
RA Blanc C., Charette S.J., Mattei S., Aubry L., Smith E.W., Cosson P.,
RA Letourneur F.;
RT "Dictyostelium Tom1 participates in an ancestral ESCRT-0 complex.";
RL Traffic 10:161-171(2009).
CC -!- FUNCTION: May be involved in clathrin-mediated endocytosis.
CC -!- SUBUNIT: Interacts with tom1. {ECO:0000269|PubMed:19054384}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
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DR EMBL; AAFI02000100; EAL63730.1; -; Genomic_DNA.
DR RefSeq; XP_637239.1; XM_632147.1.
DR AlphaFoldDB; Q54KI4; -.
DR STRING; 44689.DDB0238505; -.
DR PaxDb; Q54KI4; -.
DR EnsemblProtists; EAL63730; EAL63730; DDB_G0287325.
DR GeneID; 8626070; -.
DR KEGG; ddi:DDB_G0287325; -.
DR dictyBase; DDB_G0287325; -.
DR eggNOG; KOG0998; Eukaryota.
DR HOGENOM; CLU_271317_0_0_1; -.
DR InParanoid; Q54KI4; -.
DR OMA; ADTKNRG; -.
DR Reactome; R-DDI-193648; NRAGE signals death through JNK.
DR Reactome; R-DDI-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-DDI-8856828; Clathrin-mediated endocytosis.
DR Reactome; R-DDI-9013148; CDC42 GTPase cycle.
DR Reactome; R-DDI-9013406; RHOQ GTPase cycle.
DR Reactome; R-DDI-9013420; RHOU GTPase cycle.
DR PRO; PR:Q54KI4; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0030122; C:AP-2 adaptor complex; IDA:dictyBase.
DR GO; GO:0030132; C:clathrin coat of coated pit; IC:dictyBase.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd00052; EH; 3.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR Pfam; PF12763; EF-hand_4; 3.
DR SMART; SM00054; EFh; 5.
DR SMART; SM00027; EH; 3.
DR SUPFAM; SSF47473; SSF47473; 3.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 4.
DR PROSITE; PS50031; EH; 3.
PE 1: Evidence at protein level;
KW Calcium; Cell membrane; Coiled coil; Membrane; Protein transport;
KW Reference proteome; Repeat; Transport.
FT CHAIN 1..1196
FT /note="Epidermal growth factor receptor substrate 15
FT homolog"
FT /id="PRO_0000375888"
FT DOMAIN 10..45
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 11..100
FT /note="EH 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00077"
FT DOMAIN 46..77
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 114..149
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 115..204
FT /note="EH 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00077"
FT DOMAIN 223..310
FT /note="EH 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00077"
FT DOMAIN 254..289
FT /note="EF-hand 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REGION 309..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 790..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 822..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 905..932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 976..1082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1101..1133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1157..1196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 512..718
FT /evidence="ECO:0000255"
FT COMPBIAS 909..932
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1159..1196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1196 AA; 131394 MW; 91839037E2EEDDC1 CRC64;
MRSEAQVPPA QKVYYEELFQ IADVDKDGVI GLNDASFFRN SMLSNDILRD IWQLSDVNNG
YLNIDDFFVA LKLVSLAQMG APVTLDSIKL IPVIPPPKLN DIPPLKNDWI ISNGEKQNYI
DLFNKYDEDG DGFILGSQAK TIFGTSGLPT KMLSHIWNLS DVSKDQKLDC QEFIMATFLI
RSVLKGYELP NKLPESLITS SHYISSAGVP SPKIPEWLIP PPERIIYEDL FNKNQQGGIF
TGSQAKVLFE KSGLSNQDLK LIWDLADHNQ EQVLDKHKFV IAMFLISQRK KGKELPQSLP
QLLLESSKST FNPSSITSPP PQSSPQSSQL QQQPPQQQQQ TGDSKYNINL NDLVSNTTPI
GQPNIQPTTT TTTTPATASG GLNVSGLLSP PPQQQSPSIV GTPPSTITRE GSFTFDNSGG
GNNLLAKPPR SNSITRMNSF QHQLPQQQQQ QVSPQSTISN TSIGSGSSSF LSTNATTSSP
PPIPSTSSQP TSSNNSSITS NNNNPISPTS TNITQLFENI EKVKQQVFEQ ERIRQEEIQV
KLNQELQLEA ELKQQLAQEQ QQLDEVRENV KEEEIKLSSI KADNQSLKEQ ISTARVDIKS
LKSQLEQQSS LLREKSELFD EQNEALSHLN DDLKEKQQEL QKNKQQIEQL LSSIESIKQN
RTDVKNQIST VTKQLNDSKL ELKQLAEEQK QQKQKLAEEQ KQLQQLQQQQ QQQATSKSLT
SVKSDDNITF LSGINTNTTS TNTATSIPTA SVSGNDNWDF FNSPPVKSSS SLPTSPFDDD
KTFVPTFTTT TTTTNNNNNN NTINTSNGNL TFTSPVKSTV NQLKSSNSSV GGTGGSVSTR
KLSGASVSSN NSFNDNTSID TLNNHFGSDQ FSFNSFGSNN LTAPPTTSSS TNKVQSDFFG
VGGGNKDPFG GDSNNNPFGE ESTSSIRDGG SETLSEAHTL FDKDPLFETN DAFQSSKDPF
GQILFSNFTK DSFGGESVSN NSNNSSIISS NTIPSSNFTF NTNSTTTNNR QSPIDSDLFS
DNQQQQQQQQ QQQQQQQQQQ QQQQQPTQSN QNNQSFTSND SFDDFQTTPT PTNNNNNTTT
TEFGVKFSDT TFGDSSNGDF DFGSNVFGQP SANDPFSSSI EPQHQPDTNN VSSDPFKGGF
DDFGSAPFSF DNKFNEVVGD DSPSLTTATT TTTNDNDNGT FVFNDNNNNT PSPFDS
