ID   EPSC_BACSU              Reviewed;         598 AA.
AC   P71052; O08171; Q795I1;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Probable polysaccharide biosynthesis protein EpsC;
GN   Name=epsC; Synonyms=yveM; OrderedLocusNames=BSU34350;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168trp;
RX   PubMed=8969506; DOI=10.1099/13500872-142-11-3089;
RA   Fabret C., Quentin Y., Chapal N., Guiseppi A., Haiech J., Denizot F.;
RT   "Integrated mapping and sequencing of a 115 kb DNA fragment from Bacillus
RT   subtilis: sequence analysis of a 21 kb segment containing the sigL locus.";
RL   Microbiology 142:3089-3096(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RA   Denizot F.;
RL   Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [4]
RP   FUNCTION.
RX   PubMed=15175311; DOI=10.1128/jb.186.12.3970-3979.2004;
RA   Branda S.S., Gonzalez-Pastor J.E., Dervyn E., Ehrlich S.D., Losick R.,
RA   Kolter R.;
RT   "Genes involved in formation of structured multicellular communities by
RT   Bacillus subtilis.";
RL   J. Bacteriol. 186:3970-3979(2004).
RN   [5]
RP   NOMENCLATURE.
RX   PubMed=15661000; DOI=10.1111/j.1365-2958.2004.04440.x;
RA   Kearns D.B., Chu F., Branda S.S., Kolter R., Losick R.;
RT   "A master regulator for biofilm formation by Bacillus subtilis.";
RL   Mol. Microbiol. 55:739-749(2005).
CC   -!- FUNCTION: Involved in biofilm formation. {ECO:0000269|PubMed:15175311}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC       {ECO:0000305}.
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DR   EMBL; Z71928; CAA96491.1; -; Genomic_DNA.
DR   EMBL; Z94043; CAB08025.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15440.1; -; Genomic_DNA.
DR   PIR; B70036; B70036.
DR   RefSeq; NP_391315.1; NC_000964.3.
DR   RefSeq; WP_003244548.1; NC_000964.3.
DR   AlphaFoldDB; P71052; -.
DR   SMR; P71052; -.
DR   STRING; 224308.BSU34350; -.
DR   PaxDb; P71052; -.
DR   PRIDE; P71052; -.
DR   DNASU; 938571; -.
DR   EnsemblBacteria; CAB15440; CAB15440; BSU_34350.
DR   GeneID; 938571; -.
DR   KEGG; bsu:BSU34350; -.
DR   PATRIC; fig|224308.179.peg.3721; -.
DR   eggNOG; COG1086; Bacteria.
DR   InParanoid; P71052; -.
DR   OMA; IIIAMPS; -.
DR   PhylomeDB; P71052; -.
DR   BioCyc; BSUB:BSU34350-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:1900192; P:positive regulation of single-species biofilm formation; IMP:CACAO.
DR   CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003869; Polysac_CapD-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF02719; Polysacc_synt_2; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Exopolysaccharide synthesis; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..598
FT                   /note="Probable polysaccharide biosynthesis protein EpsC"
FT                   /id="PRO_0000360639"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   598 AA;  66266 MW;  15B22E1DBC8E828D CRC64;
     MIIALDTYLV LNSVIAGYQF LKDSYQFYDS GALLLTAVSL LLSYHVCAFL FNQYKQVWTY
     TGLGELIVLL KGITLSAAVT GVIQYAVYHT MFFRLLTACW VLQLLSIGGT RILSRVLNES
     IRKKRCASSR ALIIGAGSGG TLMVRQLLSK DEPDIIPVAF IDDDQTKHKL EIMGLPVIGG
     KESIMPAVQK LKINYIIIAI PSLRTHELQV LYKECVRTGV SIKIMPHFDE MLLGTRTAGQ
     IRDVKAEDLL GRKPVTLDTS EISNRIKGKT VLVTGAGGSI GSEICRQISA FQPKEIILLG
     HGENSIHSIY TELNGRFGKH IVFHTEIADV QDRDKMFTLM KKYEPHVVYH AAAHKHVPLM
     EHNPEEAVKN NIIGTKNVAE AADMSGTETF VLISSDKAVN PANVMGATKR FAEMIIMNLG
     KVSRTKFVAV RFGNVLGSRG SVIPIFKKQI EKGGPVTVTH PAMTRYFMTI PEASRLVIQA
     GALAKGRQIF VLDMGEPVKI VDLAKNLIHL SGYTTEQVPI EFTGIRPGEK MYEELLNKNE
     VHAEQIFPKI HIGKAVDGDW PVLMRFIEDF HELPEADLRA RLFAAINTSE EMTAASVH