ID   EPSC_RALSL              Reviewed;         375 AA.
AC   P52641;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 2.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Probable UDP-N-acetylglucosamine 2-epimerase;
DE            EC=5.1.3.14;
DE   AltName: Full=UDP-GlcNAc-2-epimerase;
GN   Name=epsC;
OS   Ralstonia solanacearum (Pseudomonas solanacearum).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=305;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AW;
RX   PubMed=7476194; DOI=10.1111/j.1365-2958.1995.tb02323.x;
RA   Huang J., Schell M.;
RT   "Molecular characterization of the eps gene cluster of Pseudomonas
RT   solanacearum and its transcriptional regulation at a single promoter.";
RL   Mol. Microbiol. 16:977-989(1995).
CC   -!- FUNCTION: May be involved in synthesis of N-acetyltrideoxygalactose, a
CC       component of exopolysaccharide EPS I which functions as a virulence
CC       factor.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-
CC         mannosamine; Xref=Rhea:RHEA:17213, ChEBI:CHEBI:57705,
CC         ChEBI:CHEBI:68623; EC=5.1.3.14;
CC   -!- PATHWAY: Glycan metabolism; exopolysaccharide EPS I biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA91626.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; U17898; AAA91626.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; P52641; -.
DR   SMR; P52641; -.
DR   STRING; 859657.RPSI07_mp1011; -.
DR   PRIDE; P52641; -.
DR   UniPathway; UPA00821; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008761; F:UDP-N-acetylglucosamine 2-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR003331; UDP_GlcNAc_Epimerase_2_dom.
DR   InterPro; IPR029767; WecB-like.
DR   PANTHER; PTHR43174; PTHR43174; 1.
DR   Pfam; PF02350; Epimerase_2; 1.
DR   TIGRFAMs; TIGR00236; wecB; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Isomerase; Lipopolysaccharide biosynthesis; Virulence.
FT   CHAIN           1..375
FT                   /note="Probable UDP-N-acetylglucosamine 2-epimerase"
FT                   /id="PRO_0000208525"
SQ   SEQUENCE   375 AA;  40944 MW;  B07B54DAC90F7889 CRC64;
     MKKVLVVFGT RPEAIKMAPL VKALQADASL QCGVCVTAQH REMLDQVLRL FDIRPDYDLN
     VMKPGQDLYE LTSNILTGVK SVLESFEPDL VLVHGDTSTT LATTLAAYYK QVPVGHIEAG
     LRTGNLYSPW PEEVNRKVTG SLAALHFAPT ERSRRNLLNE GVPADAVVVT GNTVIDALLS
     VRQRLQTDTA LCRNTASLIP YNIGERRIVL VTGHRRESFG DGFERICSTL TSIARAHPDV
     DIVYPVHLNP NVREPVGRLL KGIANIHLIE PLDYLPFVYL MDKAHIILTD SGGIQEEAPS
     LGKPVLVMRD TTERPEAVEA GTVRLVGTSV DALVDSATAL LNDDSAYEAM SRAHNPYGDG
     AASARITRAI QAYFA