ID   EPSC_RALSO              Reviewed;         375 AA.
AC   P58600;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Probable UDP-N-acetylglucosamine 2-epimerase;
DE            EC=5.1.3.14;
DE   AltName: Full=UDP-GlcNAc-2-epimerase;
GN   Name=epsC; OrderedLocusNames=RSp1017; ORFNames=RS02355;
OS   Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum).
OG   Plasmid megaplasmid Rsp.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=267608;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GMI1000;
RX   PubMed=11823852; DOI=10.1038/415497a;
RA   Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M.,
RA   Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M.,
RA   Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M.,
RA   Moisan A., Robert C., Saurin W., Schiex T., Siguier P., Thebault P.,
RA   Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A.;
RT   "Genome sequence of the plant pathogen Ralstonia solanacearum.";
RL   Nature 415:497-502(2002).
CC   -!- FUNCTION: May be involved in synthesis of N-acetyltrideoxygalactose, a
CC       component of exopolysaccharide EPS I which functions as a virulence
CC       factor. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-
CC         mannosamine; Xref=Rhea:RHEA:17213, ChEBI:CHEBI:57705,
CC         ChEBI:CHEBI:68623; EC=5.1.3.14;
CC   -!- PATHWAY: Glycan metabolism; exopolysaccharide EPS I biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAD18168.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL646053; CAD18168.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_019719623.1; NC_003296.1.
DR   AlphaFoldDB; P58600; -.
DR   SMR; P58600; -.
DR   STRING; 267608.RSp1017; -.
DR   EnsemblBacteria; CAD18168; CAD18168; RSp1017.
DR   GeneID; 60503928; -.
DR   KEGG; rso:RSp1017; -.
DR   eggNOG; COG0381; Bacteria.
DR   HOGENOM; CLU_041674_1_0_4; -.
DR   OMA; VYFVGDV; -.
DR   UniPathway; UPA00821; -.
DR   Proteomes; UP000001436; Plasmid megaplasmid Rsp.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008761; F:UDP-N-acetylglucosamine 2-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR003331; UDP_GlcNAc_Epimerase_2_dom.
DR   InterPro; IPR029767; WecB-like.
DR   PANTHER; PTHR43174; PTHR43174; 1.
DR   Pfam; PF02350; Epimerase_2; 1.
DR   TIGRFAMs; TIGR00236; wecB; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Isomerase; Lipopolysaccharide biosynthesis; Plasmid;
KW   Reference proteome; Virulence.
FT   CHAIN           1..375
FT                   /note="Probable UDP-N-acetylglucosamine 2-epimerase"
FT                   /id="PRO_0000208524"
SQ   SEQUENCE   375 AA;  40969 MW;  A9BFB435602B2AB0 CRC64;
     MKKVLVVFGT RPEAIKMAPL VKALQADTSM QCGVCVTAQH REMLDQVLRL FDIRPDYDLN
     VMKPGQDLYE LTSNILTGVK SVLESFAPDL VLVHGDTSTT LATTLAAYYK QVPVGHIEAG
     LRTGNLYSPW PEEANRKVTG SLAALHFAPT ERSRRNLLNE GVPADAVVVT GNTVIDALLS
     VRQRLQTDTA LCRHTASLIP YRIGERRIVL VTGHRRESFG DGFERICAAL ASIARAHPDV
     DIVYPVHLNP NVREPVGRLL KGIDNIHLIE PLDYLPFVYL MDKAHIILTD SGGIQEEAPS
     LGKPVLVMRD TTERPEAVEA GTVRLVGTSV DALVDSATTL LNDDSAYEAM SRAHNPYGDG
     AASARITRAI QAYFA