ID   EPYC_CHICK              Reviewed;         316 AA.
AC   Q90944;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Epiphycan;
DE   AltName: Full=Dermatan sulfate proteoglycan 3;
DE   AltName: Full=Proteoglycan-Lb;
DE            Short=PG-Lb;
DE   AltName: Full=Small chondroitin/dermatan sulfate proteoglycan;
DE   Flags: Precursor;
GN   Name=EPYC; Synonyms=DSPG3, PGLB;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=White leghorn; TISSUE=Fetal epiphyseal cartilage;
RX   PubMed=1730648; DOI=10.1016/s0021-9258(18)48424-4;
RA   Shinomura T., Kimata K.;
RT   "Proteoglycan-Lb, a small dermatan sulfate proteoglycan expressed in
RT   embryonic chick epiphyseal cartilage, is structurally related to
RT   osteoinductive factor.";
RL   J. Biol. Chem. 267:1265-1270(1992).
CC   -!- FUNCTION: May have a role in bone formation and also in establishing
CC       the ordered structure of cartilage through matrix organization.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Preferentially expressed in flattened chondrocytes
CC       of developing chick limb cartilage. Also found in the cartilage
CC       peripheral zone bordering with bone marrow cavity.
CC       {ECO:0000269|PubMed:1730648}.
CC   -!- PTM: The O-linked glycosaminoglycan chain(s) are dermatan sulfate.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC       family. SLRP class III subfamily. {ECO:0000305}.
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DR   EMBL; D10485; BAA01366.1; -; mRNA.
DR   PIR; A41781; A41781.
DR   RefSeq; NP_001004382.1; NM_001004382.1.
DR   AlphaFoldDB; Q90944; -.
DR   SMR; Q90944; -.
DR   STRING; 9031.ENSGALP00000018368; -.
DR   PaxDb; Q90944; -.
DR   Ensembl; ENSGALT00000018390; ENSGALP00000018368; ENSGALG00000011269.
DR   GeneID; 417890; -.
DR   KEGG; gga:417890; -.
DR   CTD; 1833; -.
DR   VEuPathDB; HostDB:geneid_417890; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000157574; -.
DR   HOGENOM; CLU_067583_0_0_1; -.
DR   InParanoid; Q90944; -.
DR   OMA; CLLCTCM; -.
DR   OrthoDB; 1109019at2759; -.
DR   PhylomeDB; Q90944; -.
DR   TreeFam; TF351924; -.
DR   PRO; PR:Q90944; -.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000011269; Expressed in colon.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0061975; P:articular cartilage development; IBA:GO_Central.
DR   GO; GO:0060348; P:bone development; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR027217; Epiphycan.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   InterPro; IPR043547; Mimecan/Epiphycan.
DR   PANTHER; PTHR46269; PTHR46269; 1.
DR   PANTHER; PTHR46269:SF3; PTHR46269:SF3; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00369; LRR_TYP; 4.
DR   SMART; SM00013; LRRNT; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Extracellular matrix; Glycoprotein; Leucine-rich repeat;
KW   Proteoglycan; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..316
FT                   /note="Epiphycan"
FT                   /id="PRO_0000032770"
FT   DOMAIN          100..137
FT                   /note="LRRNT"
FT   REPEAT          138..159
FT                   /note="LRR 1"
FT   REPEAT          162..183
FT                   /note="LRR 2"
FT   REPEAT          186..207
FT                   /note="LRR 3"
FT   REPEAT          232..252
FT                   /note="LRR 4"
FT   REPEAT          253..274
FT                   /note="LRR 5"
FT   REPEAT          284..304
FT                   /note="LRR 6"
FT   CARBOHYD        65
FT                   /note="O-linked (Xyl...) (dermatan sulfate) serine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        98
FT                   /note="O-linked (Xyl...) (dermatan sulfate) serine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        296
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        112..124
FT                   /evidence="ECO:0000250"
FT   DISULFID        273..306
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   316 AA;  35857 MW;  681538A251454914 CRC64;
     MKTFVNIFLG FFIFESVGAV PITDTVTYDS EFYDVSLGEL PHPFVSAEND QSDQVETEIG
     TAIPSIIQES YSSAPLTEEP EEEASTPKLI DGSSAQGSGV LVPQTQDGLP TCLLCTCLGT
     TVYCDDRELD AVPPLPKNTM YFYSRYNRIR KINKNDFANL NNLKRIDLTA NLISEIHEDA
     FRRLPQLLEL VLRDNRIRQL PELPSTLTLI DISNNRLGRK GIRNEAFKDL HELQHLYITD
     NNLDHVPLPL PESLQALHLQ NNNIQEMHED TFCKMRDFSY VRRALEDIRL DGNPINLSKT
     PYAYMCLPRL PVGNLI