ID   EQXF_GIBF5              Reviewed;         712 AA.
AC   S0DS79;
DT   25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2013, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Trichosetin biosynthesis cluster transcription factor TF23 {ECO:0000303|PubMed:28379186};
GN   Name=TF23 {ECO:0000303|PubMed:28379186}; ORFNames=FFUJ_02223;
OS   Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae
OS   and foot rot disease fungus) (Fusarium fujikuroi).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium fujikuroi species complex.
OX   NCBI_TaxID=1279085;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 195.34 / IMI 58289 / NRRL A-6831;
RX   PubMed=23825955; DOI=10.1371/journal.ppat.1003475;
RA   Wiemann P., Sieber C.M.K., von Bargen K.W., Studt L., Niehaus E.-M.,
RA   Espino J.J., Huss K., Michielse C.B., Albermann S., Wagner D.,
RA   Bergner S.V., Connolly L.R., Fischer A., Reuter G., Kleigrewe K., Bald T.,
RA   Wingfield B.D., Ophir R., Freeman S., Hippler M., Smith K.M., Brown D.W.,
RA   Proctor R.H., Muensterkoetter M., Freitag M., Humpf H.-U., Gueldener U.,
RA   Tudzynski B.;
RT   "Deciphering the cryptic genome: genome-wide analyses of the rice pathogen
RT   Fusarium fujikuroi reveal complex regulation of secondary metabolism and
RT   novel metabolites.";
RL   PLoS Pathog. 9:E1003475-E1003475(2013).
RN   [2]
RP   FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=28379186; DOI=10.3390/toxins9040126;
RA   Janevska S., Arndt B., Baumann L., Apken L.H., Mauriz Marques L.M.,
RA   Humpf H.U., Tudzynski B.;
RT   "Establishment of the inducible Tet-On system for the activation of the
RT   silent trichosetin gene cluster in Fusarium fujikuroi.";
RL   Toxins 9:0-0(2017).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of trichosetin, a trans-
CC       fused decalin-containing tetramic acid with antimicrobial activity
CC       (PubMed:28379186). Plays a specific role in the induction of the
CC       cluster-specific MFS transporter MFS-T and thus regulates the
CC       detoxification of the toxic trichosetin in Gibberella fujikuroi cells
CC       (PubMed:28379186). {ECO:0000269|PubMed:28379186}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- INDUCTION: Expression is induced by the final product trichosetin and
CC       not by the trichosetin cluster-specific transcription acticator TF22
CC       (PubMed:28379186). {ECO:0000269|PubMed:28379186}.
CC   -!- DISRUPTION PHENOTYPE: Resulted in the down-regulation of the three
CC       biosynthetic genes from the trisetin cluster and a reduced accumulation
CC       of trichosetin, and blocks the expression of the cluster-specific MFS
CC       transporter MFS-T (PubMed:28379186). {ECO:0000269|PubMed:28379186}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HF679025; CCT65290.1; -; Genomic_DNA.
DR   AlphaFoldDB; S0DS79; -.
DR   EnsemblFungi; CCT65290; CCT65290; FFUJ_02223.
DR   VEuPathDB; FungiDB:FFUJ_02223; -.
DR   HOGENOM; CLU_007426_5_0_1; -.
DR   Proteomes; UP000016800; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   SMART; SM00906; Fungal_trans; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..712
FT                   /note="Trichosetin biosynthesis cluster transcription
FT                   factor TF23"
FT                   /id="PRO_0000443991"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          302..379
FT                   /note="Fungal transcription factor"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   712 AA;  79118 MW;  25FE0FF2BB42F354 CRC64;
     MEWGPGKTAQ GRARLPSSRP REKPQLSCNL CGDAAHQPRV TTQDRIRHLE SLVFDLMQQS
     SVTQGQHGGG TPFSPVGSAR FPVNTAVATT GTDSGSMRST GGGANYVVSS HWAAVLDGIA
     ELKDHLDSED EAVHSDVHGV ESPTAEITGP QLLYGCPKPA SKDEILASIL SLSRPVVDRL
     VSRYFNSFEM SPAVLHSVEF LKEYEEFWDD PSSVSPLWLG LLFTIMCLAT QFEKFRLDPG
     VQSPAALSME RDLQKMADAY KLRIGQCLVL GNYTKGGPYV LETLMLYIAA EVFSSTDAEI
     DIWILTGNTV QIALHMGYHR DPKHFKGMSS FAAEMRRRVW ATLIEMDLGL SAQMGLPRMI
     KQWQTDTQEP SNLQDSDFDK ATVEMPPSRP ETELTPILYR LVKARLMTTV GYIWDFAADV
     RPYTYTEVER MDSKLDEARK SIPDCLKWHS FARCITDSPQ IIMQKVVLET LVYRAKIILH
     RKFMLGPPEN SADSKRIVLE SALKLLDYQH MLQEESQPFC QLYQERWRVS SLVNHDFLLA
     TSILCYYLQN TKREGMPVSE STPMDETIMV SLRRSYDIWL QSSDSSKEAR KVVKALNVVL
     GVSNTSGTDS GLDSSMSSSV PSGCASSTIN DYQSGVEIPA GLGSQFPVLD GAMMPNWATF
     ADDLLAAPMA TPSNEWQAMD AAETVDTMGS LAWPWNLQCH ALAEKVNDES LD