ID   EQXR_FUSHE              Reviewed;         469 AA.
AC   S4W177;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2013, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Equisetin cluster transcription factor eqxR {ECO:0000303|PubMed:23614392};
DE   AltName: Full=Equisetin biosynthesis protein R {ECO:0000303|PubMed:23614392};
GN   Name=eqxR {ECO:0000303|PubMed:23614392};
OS   Fusarium heterosporum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium heterosporum species complex.
OX   NCBI_TaxID=42747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND PATHWAY.
RC   STRAIN=ATCC 74349 / MF6069;
RX   PubMed=23614392; DOI=10.1021/cb400159f;
RA   Kakule T.B., Sardar D., Lin Z., Schmidt E.W.;
RT   "Two related pyrrolidinedione synthetase loci in Fusarium heterosporum ATCC
RT   74349 produce divergent metabolites.";
RL   ACS Chem. Biol. 8:1549-1557(2013).
RN   [2]
RP   FUNCTION.
RX   PubMed=25226362; DOI=10.1021/sb500296p;
RA   Kakule T.B., Jadulco R.C., Koch M., Janso J.E., Barrows L.R., Schmidt E.W.;
RT   "Native promoter strategy for high-yielding synthesis and engineering of
RT   fungal secondary metabolites.";
RL   ACS Synth. Biol. 4:625-633(2015).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of Equisetin
CC       (PubMed:23614392). {ECO:0000305|PubMed:23614392}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KC439347; AGO86667.1; -; Genomic_DNA.
DR   AlphaFoldDB; S4W177; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..469
FT                   /note="Equisetin cluster transcription factor eqxR"
FT                   /id="PRO_0000441304"
FT   DNA_BIND        13..47
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          58..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..84
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   469 AA;  51402 MW;  F506673B46BAB3BF CRC64;
     MSTQNNQSIR SSCDRCRSHK LKCTVAPENS RSGSNRCTRC IRAQVTCVFG HRSQSKRSTN
     VKKADIKSGT NSQETTSMQA STIVPGRVSV SPDLWVGRQE VEEGLPIGSD GGPSMGDGDL
     WAELGTNHDL NVFDLTPSSL PTYNSQQQFS ATDFCSAPMV PHSDLSAINS QEWQFDVSEH
     PDQTTTAPHV IVQLSALVTN IHETSKSLGE SFWASLAESS QLKNYPIGRV LSLSQDFTAI
     LECIWMSKTM DYKQSSSFVT SESDGQDGIS SFELEDVLDY GELLSTVGTS PGRSDFSTST
     HSSVATAVDM PTMLLVLSCY TSLTKLYSLV FEHFESHLSH LPHSYTSPTS HTSPRWGLGL
     QLGELPSADE TCTKVYTAVQ ILLDAFQSVE DVVGLPRSLS AVRQQTCGKE EEAESGDVFN
     RASLWTDFLA KSVFKATVKG TSEEDCEEIR QLSIKVKSLK ALIRERMKL