ID   EQXR_GIBF5              Reviewed;         454 AA.
AC   S0DRT4;
DT   25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2013, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Trichosetin biosynthesis cluster transcription factor TF22 {ECO:0000303|PubMed:28379186};
GN   Name=TF22 {ECO:0000303|PubMed:28379186}; ORFNames=FFUJ_02222;
OS   Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae
OS   and foot rot disease fungus) (Fusarium fujikuroi).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium fujikuroi species complex.
OX   NCBI_TaxID=1279085;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 195.34 / IMI 58289 / NRRL A-6831;
RX   PubMed=23825955; DOI=10.1371/journal.ppat.1003475;
RA   Wiemann P., Sieber C.M.K., von Bargen K.W., Studt L., Niehaus E.-M.,
RA   Espino J.J., Huss K., Michielse C.B., Albermann S., Wagner D.,
RA   Bergner S.V., Connolly L.R., Fischer A., Reuter G., Kleigrewe K., Bald T.,
RA   Wingfield B.D., Ophir R., Freeman S., Hippler M., Smith K.M., Brown D.W.,
RA   Proctor R.H., Muensterkoetter M., Freitag M., Humpf H.-U., Gueldener U.,
RA   Tudzynski B.;
RT   "Deciphering the cryptic genome: genome-wide analyses of the rice pathogen
RT   Fusarium fujikuroi reveal complex regulation of secondary metabolism and
RT   novel metabolites.";
RL   PLoS Pathog. 9:E1003475-E1003475(2013).
RN   [2]
RP   FUNCTION.
RX   PubMed=28379186; DOI=10.3390/toxins9040126;
RA   Janevska S., Arndt B., Baumann L., Apken L.H., Mauriz Marques L.M.,
RA   Humpf H.U., Tudzynski B.;
RT   "Establishment of the inducible Tet-On system for the activation of the
RT   silent trichosetin gene cluster in Fusarium fujikuroi.";
RL   Toxins 9:0-0(2017).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of trichosetin, a trans-
CC       fused decalin-containing tetramic acid with antimicrobial activity
CC       (PubMed:28379186). Directly activates expression of only the three
CC       biosynthetic genes PKS-NRPS1, DA and ER, while TF23 and MFS-T are
CC       induced by the final product trichosetin and not by TF22
CC       (PubMed:28379186). {ECO:0000269|PubMed:28379186}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; HF679025; CCT65289.1; -; Genomic_DNA.
DR   AlphaFoldDB; S0DRT4; -.
DR   SMR; S0DRT4; -.
DR   EnsemblFungi; CCT65289; CCT65289; FFUJ_02222.
DR   VEuPathDB; FungiDB:FFUJ_02222; -.
DR   HOGENOM; CLU_047997_0_0_1; -.
DR   Proteomes; UP000016800; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..454
FT                   /note="Trichosetin biosynthesis cluster transcription
FT                   factor TF22"
FT                   /id="PRO_0000443990"
FT   DNA_BIND        13..47
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          51..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..73
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   454 AA;  49562 MW;  B2796F21F0CA4B9D CRC64;
     MSTRNSQSIR SSCDRCRSHK LKCTVSPEDS RSGPHKCTRC IRAQVTCVFG PRSQSKRTPN
     GKNKPEKPKP ELEPPQKTSP PVCSSSLAGM DLGSPGAWTP WIDDLASQET EEPLPIDVNT
     AGDGSGPSDG DFWADLGMTQ ELNMLELAPT NTYQAQYLAS FDYVAPPVAE VGHLMDISEP
     SEHTPPHAIV QLSTLVTKIH ETSKALEESP WSNVPDAKQL QNYPIGRVLS LSQDFCSILG
     CIWGKVSISS DGQSSGSGSS PTPSADMLDY AEVLSSIKIT QDPTASSSMA ASVDMPTALL
     VLSCYTSLIK LYSLVFAHFE NHLSHLPEIP SPYPSQAALA SHRWGLQLGE LPSADETCTK
     ICTAVQVLLD AFQSVEDVFG LPRSFSAVRQ RTCDMEGMDF SAELGRTSLW TDYMVHFVVR
     SNAIRADTEE CEEMRELSTK VRSLKALIRE KMNL