AGP18_ARATH
ID AGP18_ARATH Reviewed; 209 AA.
AC Q9FPR2; Q945Q3; Q9SZU5;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Lysine-rich arabinogalactan protein 18;
DE Short=Lys-rich AGP 18;
DE Flags: Precursor;
GN Name=AGP18; OrderedLocusNames=At4g37450; ORFNames=F6G17.100;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11732052; DOI=10.1007/bf01280309;
RA Gilson P.R., Gaspar Y.M., Oxley D., Youl J.J., Bacic A.;
RT "NaAGP4 is an arabinogalactan protein whose expression is suppressed by
RT wounding and fungal infection in Nicotiana alata.";
RL Protoplasma 215:128-139(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12177459; DOI=10.1104/pp.003459;
RA Schultz C.J., Rumsewicz M.P., Johnson K.L., Jones B.J., Gaspar Y.M.,
RA Bacic A.;
RT "Using genomic resources to guide research directions. The arabinogalactan
RT protein gene family as a test case.";
RL Plant Physiol. 129:1448-1463(2002).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=15286287; DOI=10.1104/pp.104.045542;
RA Gaspar Y.M., Nam J., Schultz C.J., Lee L.-Y., Gilson P.R., Gelvin S.B.,
RA Bacic A.;
RT "Characterization of the Arabidopsis lysine-rich arabinogalactan-protein
RT AtAGP17 mutant (rat1) that results in a decreased efficiency of
RT agrobacterium transformation.";
RL Plant Physiol. 135:2162-2171(2004).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=15840645; DOI=10.1093/pcp/pci106;
RA Sun W., Xu J., Yang J., Kieliszewski M.J., Showalter A.M.;
RT "The lysine-rich arabinogalactan-protein subfamily in Arabidopsis: gene
RT expression, glycoprotein purification and biochemical characterization.";
RL Plant Cell Physiol. 46:975-984(2005).
CC -!- FUNCTION: Proteoglycan that seems to be implicated in diverse
CC developmental roles such as differentiation, cell-cell recognition,
CC embryogenesis and programmed cell death.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in flowers, and moderately
CC expressed in roots, stems and young leaves.
CC {ECO:0000269|PubMed:15286287, ECO:0000269|PubMed:15840645}.
CC -!- PTM: O-glycosylated on the hydroxyproline residues. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the lysine-rich AGP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM16184.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAB38212.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB80410.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF305940; AAG41964.1; -; mRNA.
DR EMBL; AL035601; CAB38212.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161591; CAB80410.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE86796.1; -; Genomic_DNA.
DR EMBL; AF411780; AAL06470.1; ALT_SEQ; mRNA.
DR EMBL; AY094028; AAM16184.1; ALT_SEQ; mRNA.
DR PIR; T04739; T04739.
DR RefSeq; NP_568027.1; NM_119909.3.
DR AlphaFoldDB; Q9FPR2; -.
DR BioGRID; 15181; 1.
DR IntAct; Q9FPR2; 1.
DR STRING; 3702.AT4G37450.1; -.
DR PaxDb; Q9FPR2; -.
DR ProteomicsDB; 244698; -.
DR EnsemblPlants; AT4G37450.1; AT4G37450.1; AT4G37450.
DR GeneID; 829900; -.
DR Gramene; AT4G37450.1; AT4G37450.1; AT4G37450.
DR KEGG; ath:AT4G37450; -.
DR Araport; AT4G37450; -.
DR TAIR; locus:2126337; AT4G37450.
DR eggNOG; ENOG502S14T; Eukaryota.
DR HOGENOM; CLU_088398_0_0_1; -.
DR InParanoid; Q9FPR2; -.
DR OMA; YVMLLRD; -.
DR PRO; PR:Q9FPR2; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9FPR2; baseline and differential.
DR Genevisible; Q9FPR2; AT.
DR GO; GO:0031225; C:anchored component of membrane; TAS:TAIR.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0009554; P:megasporogenesis; IMP:TAIR.
DR InterPro; IPR044981; AGP9/17/18.
DR PANTHER; PTHR37209; PTHR37209; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Proteoglycan; Reference proteome; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..183
FT /note="Lysine-rich arabinogalactan protein 18"
FT /id="PRO_0000269033"
FT PROPEP 184..209
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000269034"
FT REGION 21..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..125
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..167
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 183
FT /note="GPI-anchor amidated glycine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 209 AA; 20489 MW; D7B46FE0B657C6C2 CRC64;
MDRNFLLTVT LICIVVAGVG GQSPISSPTK SPTTPSAPTT SPTKSPAVTS PTTAPAKTPT
ASASSPVESP KSPAPVSESS PPPTPVPESS PPVPAPMVSS PVSSPPVPAP VADSPPAPVA
APVADVPAPA PSKHKKTTKK SKKHQAAPAP APELLGPPAP PTESPGPNSD AFSPGPSADD
QSGAASTRVL RNVAVGAVAT AWAVLVMAF
