ID   AGP19_ARATH             Reviewed;         248 AA.
AC   Q9S740; F4HYX4;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-FEB-2012, sequence version 2.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Lysine-rich arabinogalactan protein 19;
DE            Short=Lys-rich AGP 19;
DE   Flags: Precursor;
GN   Name=AGP19; OrderedLocusNames=At1g68725; ORFNames=F14K14.17, F24J5.4;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=12177459; DOI=10.1104/pp.003459;
RA   Schultz C.J., Rumsewicz M.P., Johnson K.L., Jones B.J., Gaspar Y.M.,
RA   Bacic A.;
RT   "Using genomic resources to guide research directions. The arabinogalactan
RT   protein gene family as a test case.";
RL   Plant Physiol. 129:1448-1463(2002).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=15840645; DOI=10.1093/pcp/pci106;
RA   Sun W., Xu J., Yang J., Kieliszewski M.J., Showalter A.M.;
RT   "The lysine-rich arabinogalactan-protein subfamily in Arabidopsis: gene
RT   expression, glycoprotein purification and biochemical characterization.";
RL   Plant Cell Physiol. 46:975-984(2005).
CC   -!- FUNCTION: Proteoglycan that seems to be implicated in diverse
CC       developmental roles such as differentiation, cell-cell recognition,
CC       embryogenesis and programmed cell death.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC       anchor {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Strongly expressed in stems, moderately expressed
CC       in flowers and roots and weakly expressed in young leaves.
CC       {ECO:0000269|PubMed:15840645}.
CC   -!- PTM: O-glycosylated on the hydroxyproline residues. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the lysine-rich AGP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD49970.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AAG52045.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC008075; AAD49970.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AC011914; AAG52045.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE34832.1; -; Genomic_DNA.
DR   PIR; H96711; H96711.
DR   RefSeq; NP_177041.3; NM_105546.3.
DR   AlphaFoldDB; Q9S740; -.
DR   STRING; 3702.AT1G68725.1; -.
DR   PaxDb; Q9S740; -.
DR   EnsemblPlants; AT1G68725.1; AT1G68725.1; AT1G68725.
DR   GeneID; 843203; -.
DR   Gramene; AT1G68725.1; AT1G68725.1; AT1G68725.
DR   KEGG; ath:AT1G68725; -.
DR   Araport; AT1G68725; -.
DR   TAIR; locus:2824488; AT1G68725.
DR   eggNOG; ENOG502S0NY; Eukaryota.
DR   HOGENOM; CLU_083753_0_0_1; -.
DR   OMA; GYEYNVP; -.
DR   OrthoDB; 1629877at2759; -.
DR   PRO; PR:Q9S740; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9S740; baseline and differential.
DR   GO; GO:0031225; C:anchored component of membrane; TAS:TAIR.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR038793; AGP19.
DR   PANTHER; PTHR36549; PTHR36549; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Proteoglycan; Reference proteome; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..196
FT                   /note="Lysine-rich arabinogalactan protein 19"
FT                   /id="PRO_0000269035"
FT   PROPEP          197..248
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000269036"
FT   REGION          25..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..39
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..171
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        172..188
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..208
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           196
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   248 AA;  24484 MW;  F026311C6EBFB823 CRC64;
     MESNSIIWSL LLASALISSF SVNAQGPAAS PVTSTTTAPP PTTAAPPTTA APPPTTTTPP
     VSAAQPPASP VTPPPAVTPT SPPAPKVAPV ISPATPPPQP PQSPPASAPT VSPPPVSPPP
     APTSPPPTPA SPPPAPASPP PAPASPPPAP VSPPPVQAPS PISLPPAPAP APTKHKRKHK
     HKRHHHAPAP APIPPSPPSP PVLTDPQDTA PAPSPNTNGG NALNQLKGRA VMWLNTGLVI
     LFLLAMTA