AGP24_ARATH
ID AGP24_ARATH Reviewed; 69 AA.
AC Q5PP12; Q8LE23;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Arabinogalactan protein 24 {ECO:0000303|PubMed:12177459};
DE Short=AtAGP24 {ECO:0000303|PubMed:12177459};
DE AltName: Full=Arabinogalactan peptide 24 {ECO:0000303|PubMed:12177459};
DE Short=AG-peptide 24 {ECO:0000303|PubMed:12177459};
DE Flags: Precursor;
GN Name=AGP24 {ECO:0000303|PubMed:12177459}; OrderedLocusNames=At5g40730;
GN ORFNames=MNF13.250;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9628582; DOI=10.1093/dnares/5.1.41;
RA Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence
RT features of the regions of 1,456,315 bp covered by nineteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:41-54(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP PROTEIN SEQUENCE OF 26-42, HYDROXYLATION AT PRO-34; PRO-36; PRO-38 AND
RP PRO-40, GLYCOSYLATION AT PRO-34; PRO-36; PRO-38 AND PRO-40, AND GPI-ANCHOR
RP AT SER-42.
RX PubMed=15322080; DOI=10.1074/jbc.m407594200;
RA Schultz C.J., Ferguson K.L., Lahnstein J., Bacic A.;
RT "Post-translational modifications of arabinogalactan-peptides of
RT Arabidopsis thaliana. Endoplasmic reticulum and
RT glycosylphosphatidylinositol-anchor signal cleavage sites and hydroxylation
RT of proline.";
RL J. Biol. Chem. 279:45503-45511(2004).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12177459; DOI=10.1104/pp.003459;
RA Schultz C.J., Rumsewicz M.P., Johnson K.L., Jones B.J., Gaspar Y.M.,
RA Bacic A.;
RT "Using genomic resources to guide research directions. The arabinogalactan
RT protein gene family as a test case.";
RL Plant Physiol. 129:1448-1463(2002).
CC -!- FUNCTION: Proteoglycan that seems to be implicated in diverse
CC developmental roles such as differentiation, cell-cell recognition,
CC embryogenesis and programmed cell death. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000269|PubMed:15322080}.
CC -!- PTM: Contains 4-hydroxyproline; hydroxylated on Pro-34, Pro-36, Pro-38
CC and Pro-40. {ECO:0000269|PubMed:15322080}.
CC -!- PTM: O-glycosylated on hydroxyprolines; noncontiguous hydroxylproline
CC residues are glycosylated with arabinogalactan.
CC {ECO:0000305|PubMed:15322080}.
CC -!- SIMILARITY: Belongs to the AG-peptide AGP family. {ECO:0000305}.
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DR EMBL; AB009052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED94588.1; -; Genomic_DNA.
DR EMBL; BT020285; AAV84506.1; -; mRNA.
DR EMBL; BT025562; ABF58980.1; -; mRNA.
DR EMBL; AY085662; AAM67306.1; -; mRNA.
DR RefSeq; NP_198889.1; NM_123438.3.
DR AlphaFoldDB; Q5PP12; -.
DR BioGRID; 19324; 1.
DR STRING; 3702.AT5G40730.1; -.
DR PaxDb; Q5PP12; -.
DR PRIDE; Q5PP12; -.
DR EnsemblPlants; AT5G40730.1; AT5G40730.1; AT5G40730.
DR GeneID; 834073; -.
DR Gramene; AT5G40730.1; AT5G40730.1; AT5G40730.
DR KEGG; ath:AT5G40730; -.
DR Araport; AT5G40730; -.
DR TAIR; locus:2168813; AT5G40730.
DR HOGENOM; CLU_2779330_0_0_1; -.
DR InParanoid; Q5PP12; -.
DR OMA; ATNMFTV; -.
DR PRO; PR:Q5PP12; -.
DR Proteomes; UP000006548; Chromosome 5.
DR Genevisible; Q5PP12; AT.
DR GO; GO:0031225; C:anchored component of membrane; TAS:TAIR.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Cell membrane; Direct protein sequencing; Glycoprotein; GPI-anchor;
KW Hydroxylation; Lipoprotein; Membrane; Proteoglycan; Reference proteome;
KW Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000269|PubMed:15322080"
FT PEPTIDE 26..42
FT /note="Arabinogalactan protein 24"
FT /evidence="ECO:0000269|PubMed:15322080"
FT /id="PRO_0000269029"
FT PROPEP 43..69
FT /note="Removed in mature form"
FT /evidence="ECO:0000305|PubMed:15322080"
FT /id="PRO_0000269030"
FT MOD_RES 34
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:15322080"
FT MOD_RES 36
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:15322080"
FT MOD_RES 38
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:15322080"
FT MOD_RES 40
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:15322080"
FT LIPID 42
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000269|PubMed:15322080"
FT CARBOHYD 34
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000305|PubMed:15322080"
FT CARBOHYD 36
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000305|PubMed:15322080"
FT CARBOHYD 38
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000305|PubMed:15322080"
FT CARBOHYD 40
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000305|PubMed:15322080"
FT CONFLICT 5
FT /note="T -> K (in Ref. 4; AAM67306)"
FT /evidence="ECO:0000305"
FT CONFLICT 24
FT /note="S -> F (in Ref. 4; AAM67306)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 69 AA; 7051 MW; 4794DF5C8B6176C1 CRC64;
MMMMTKMFVQ IAVVCLLATM AVVSAHEGHH HHAPAPAPGP ASSSTVVSAT NMFTVLAIAA
VALVVGSNH
