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ERB1_AJECN
ID   ERB1_AJECN              Reviewed;         788 AA.
AC   A6QX61;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE   AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN   Name=ERB1 {ECO:0000255|HAMAP-Rule:MF_03027}; ORFNames=HCAG_01968;
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma;
OC   unclassified Histoplasma.
OX   NCBI_TaxID=2059318;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: Component of the NOP7 complex, which is required for
CC       maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC       YTM1. The complex is held together by ERB1, which interacts with NOP7
CC       via its N-terminal domain and with YTM1 via a high-affinity interaction
CC       between the seven-bladed beta-propeller domains of the 2 proteins. The
CC       NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC       Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDN04103.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CH476655; EDN04103.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_001544921.1; XM_001544871.1.
DR   AlphaFoldDB; A6QX61; -.
DR   SMR; A6QX61; -.
DR   STRING; 339724.A6QX61; -.
DR   EnsemblFungi; EDN04103; EDN04103; HCAG_01968.
DR   GeneID; 5449893; -.
DR   KEGG; aje:HCAG_01968; -.
DR   HOGENOM; CLU_011390_0_1_1; -.
DR   OrthoDB; 759498at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..788
FT                   /note="Ribosome biogenesis protein ERB1"
FT                   /id="PRO_0000370414"
FT   REPEAT          433..472
FT                   /note="WD 1"
FT   REPEAT          476..516
FT                   /note="WD 2"
FT   REPEAT          613..651
FT                   /note="WD 3"
FT   REPEAT          654..699
FT                   /note="WD 4"
FT   REPEAT          703..742
FT                   /note="WD 5"
FT   REPEAT          758..788
FT                   /note="WD 6"
FT   REGION          1..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..54
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..76
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..91
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   788 AA;  88266 MW;  F9E9E39416D930B6 CRC64;
     MGDLKGSRKR KAVTRDLDEE PGVVSGDELN LDALDGDLSD KSHDTEHSSD SEIELVDDLS
     SDDGEEYEDE FDSDEIPSDI ESKPIREKSK PDRGVDIFVR GEEVTSDGEL GDGYDDDKLN
     YRVTKDANGN ERYIYDEINP DDNSDYSEAD ENANTIGNIP LSFYDQYPHI GYNINGKKIM
     RPAMGQALDT LLDSIELPKG FTGLTDPSTG KPLELNQDEL ELLRKVQMNE ITEDGYDPYQ
     PTIEYFTSKL EIMPLNAAPE PKRRFVPSKH EAKRVMKLVK AIREGRILPY KPLTEKAEAE
     EGVWTYDLWA NETPRADHPM HIPAPKLPPP GYEESYHPPP EYLPDEKEKA AWLNTDPEDR
     EREYLPADYD ALRKVPGYDS FVKEKFERCL DLYLAPRVRR SKLNIDPESL LPKLPSPEEL
     KPFPSTCATL FRGHSGRVRT LAIDPTGVWL ASGGDDGTVR VWELLTGRQI WSVKLSDEEP
     VNVIRWRPSK DAVVLAAATG DSIHLIVPPI LDPEMEKASL DIVDAGWGYA KTLTSDSTKK
     TSAQWTRPSP SLLDSGVQAV ISLGYVAKSL SWHRRGDYFV TVCPGTATPV SLAIAIHTLS
     KHLTQHPFRR RLKGGGPPQA AHFHPSKPIL FVANQRTIRS YDLSRQSLVK ILQPGARWIS
     SFDIHPTSST TSGGDNLIVG SYDRRLLWHD VDLSPRPYKT LRYHQKAIRA VRYHSNYPLF
     ADASDDGSLQ IFHGSVTGDL LSNASIVPLK VLRGHKVTGE LGVLDLDWHP REAWCVSAGA
     DGTCRLWT
 
 
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