ERB1_AJECN
ID ERB1_AJECN Reviewed; 788 AA.
AC A6QX61;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=ERB1 {ECO:0000255|HAMAP-Rule:MF_03027}; ORFNames=HCAG_01968;
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma;
OC unclassified Histoplasma.
OX NCBI_TaxID=2059318;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24;
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDN04103.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH476655; EDN04103.1; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_001544921.1; XM_001544871.1.
DR AlphaFoldDB; A6QX61; -.
DR SMR; A6QX61; -.
DR STRING; 339724.A6QX61; -.
DR EnsemblFungi; EDN04103; EDN04103; HCAG_01968.
DR GeneID; 5449893; -.
DR KEGG; aje:HCAG_01968; -.
DR HOGENOM; CLU_011390_0_1_1; -.
DR OrthoDB; 759498at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..788
FT /note="Ribosome biogenesis protein ERB1"
FT /id="PRO_0000370414"
FT REPEAT 433..472
FT /note="WD 1"
FT REPEAT 476..516
FT /note="WD 2"
FT REPEAT 613..651
FT /note="WD 3"
FT REPEAT 654..699
FT /note="WD 4"
FT REPEAT 703..742
FT /note="WD 5"
FT REPEAT 758..788
FT /note="WD 6"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..54
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..76
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 788 AA; 88266 MW; F9E9E39416D930B6 CRC64;
MGDLKGSRKR KAVTRDLDEE PGVVSGDELN LDALDGDLSD KSHDTEHSSD SEIELVDDLS
SDDGEEYEDE FDSDEIPSDI ESKPIREKSK PDRGVDIFVR GEEVTSDGEL GDGYDDDKLN
YRVTKDANGN ERYIYDEINP DDNSDYSEAD ENANTIGNIP LSFYDQYPHI GYNINGKKIM
RPAMGQALDT LLDSIELPKG FTGLTDPSTG KPLELNQDEL ELLRKVQMNE ITEDGYDPYQ
PTIEYFTSKL EIMPLNAAPE PKRRFVPSKH EAKRVMKLVK AIREGRILPY KPLTEKAEAE
EGVWTYDLWA NETPRADHPM HIPAPKLPPP GYEESYHPPP EYLPDEKEKA AWLNTDPEDR
EREYLPADYD ALRKVPGYDS FVKEKFERCL DLYLAPRVRR SKLNIDPESL LPKLPSPEEL
KPFPSTCATL FRGHSGRVRT LAIDPTGVWL ASGGDDGTVR VWELLTGRQI WSVKLSDEEP
VNVIRWRPSK DAVVLAAATG DSIHLIVPPI LDPEMEKASL DIVDAGWGYA KTLTSDSTKK
TSAQWTRPSP SLLDSGVQAV ISLGYVAKSL SWHRRGDYFV TVCPGTATPV SLAIAIHTLS
KHLTQHPFRR RLKGGGPPQA AHFHPSKPIL FVANQRTIRS YDLSRQSLVK ILQPGARWIS
SFDIHPTSST TSGGDNLIVG SYDRRLLWHD VDLSPRPYKT LRYHQKAIRA VRYHSNYPLF
ADASDDGSLQ IFHGSVTGDL LSNASIVPLK VLRGHKVTGE LGVLDLDWHP REAWCVSAGA
DGTCRLWT