ERB1_ASHGO
ID ERB1_ASHGO Reviewed; 827 AA.
AC Q75DC5;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2013, sequence version 2.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=ERB1 {ECO:0000255|HAMAP-Rule:MF_03027}; OrderedLocusNames=ABR101C;
GN ORFNames=AGOS_ABR101C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION, AND SEQUENCE REVISION TO 356.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; AE016815; AAS50872.2; -; Genomic_DNA.
DR RefSeq; NP_983048.2; NM_208401.2.
DR AlphaFoldDB; Q75DC5; -.
DR SMR; Q75DC5; -.
DR STRING; 33169.AAS50872; -.
DR EnsemblFungi; AAS50872; AAS50872; AGOS_ABR101C.
DR GeneID; 4619152; -.
DR KEGG; ago:AGOS_ABR101C; -.
DR eggNOG; KOG0650; Eukaryota.
DR HOGENOM; CLU_011390_0_1_1; -.
DR InParanoid; Q75DC5; -.
DR OMA; MRPAKGE; -.
DR Proteomes; UP000000591; Chromosome II.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IBA:GO_Central.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:EnsemblFungi.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IBA:GO_Central.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..827
FT /note="Ribosome biogenesis protein ERB1"
FT /id="PRO_0000370415"
FT REPEAT 461..500
FT /note="WD 1"
FT REPEAT 509..549
FT /note="WD 2"
FT REPEAT 657..695
FT /note="WD 3"
FT REPEAT 698..737
FT /note="WD 4"
FT REPEAT 741..780
FT /note="WD 5"
FT REPEAT 796..827
FT /note="WD 6"
FT REGION 1..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..409
FT /note="Required for interaction with NOP7"
FT /evidence="ECO:0000250"
FT REGION 409..445
FT /note="Required for interaction with YTM1"
FT /evidence="ECO:0000250"
FT COMPBIAS 1..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..57
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..102
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 827 AA; 93519 MW; B717C8022CCB787D CRC64;
MVHSKKDKSV MKHSDIKKRG AAVLEEEDVL QQDEQLLVDG ATIDCDSDDD EEFQSAEEEV
LSSGSESSSK EGSTPGSPVE GSDEEAEDED ADEEEDEDAE FNRLLAAEEG DSEGEYGSED
FSDDNDTRPL REKLSSMQLK MIPDGESASV KTRYSDGTPR IIKPEITPVY DSDDTDVETA
NTIGNIPLSA YDEMPHIGYD INGKRIMRPA KGSALDALLD TIELPEGWTG LLDQNTGSSL
NLTPEELDLI SKIQKNEQVD DSVDPYEPYV DWFTRHEEIM PVTAIPEPKR RFVPSKHEAK
RIMKIVKAIR EGRIIPPNKL RELREQEQAN NFSYDLWGDS EETNEHIMNL RAPKLPPPTN
EESYNPPEEY LLTPEERAEW EKMDPSDRKR NFLPQKYGSL RKVPGYGESV RERFERSLDL
YLAPRVRKNK LNIDPESLIP ELPSPKDLRP FPIRCSTVYA GHKGKIRTLS IDPSGLWLAT
GSDDGTVRVW EILTGREVYK ATIVDIKNNQ DDHIETVEWN PDKTVGLLAV AAGENIYLLV
PPIFGFEVEN NSRLKIENGY GFDTFGNVKK SALNVNSDDE QAETEATVKK QVAQWNKPTQ
KQAENDVAIV ITCRKTVKKI SWHRKGDYFV SVQPESGHTS VLIHQLSKHL TQSPFNKSKG
IIMDAKFHPF KPQLFVCSQR YIRIYDLSQQ VLVKKLLPGA RWLSTIDIHP RGDNLIASSF
DKRVLWHDLD LAATPYKTLR YHEKAVRSVG FHKKLPLFCS AADDGTIHVF HGTVYDDMMK
NPLLVPLKKL TGHKLVNSLG VLDTVWHPRE AWLFSAGADN TARLWTT
