ERB1_ASPCL
ID ERB1_ASPCL Reviewed; 788 AA.
AC A1CQI9;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Ribosome biogenesis protein erb1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=erb1; ORFNames=ACLA_026270;
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of erb1, nop7 and
CC ytm1. The complex is held together by erb1, which interacts with nop7
CC via its N-terminal domain and with ytm1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; DS027059; EAW07910.1; -; Genomic_DNA.
DR RefSeq; XP_001269336.1; XM_001269335.1.
DR AlphaFoldDB; A1CQI9; -.
DR SMR; A1CQI9; -.
DR STRING; 5057.CADACLAP00002907; -.
DR EnsemblFungi; EAW07910; EAW07910; ACLA_026270.
DR GeneID; 4701900; -.
DR KEGG; act:ACLA_026270; -.
DR VEuPathDB; FungiDB:ACLA_026270; -.
DR eggNOG; KOG0650; Eukaryota.
DR HOGENOM; CLU_011390_0_1_1; -.
DR OMA; MRPAKGE; -.
DR OrthoDB; 759498at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IEA:EnsemblFungi.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:EnsemblFungi.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..788
FT /note="Ribosome biogenesis protein erb1"
FT /id="PRO_0000370416"
FT REPEAT 426..465
FT /note="WD 1"
FT REPEAT 469..509
FT /note="WD 2"
FT REPEAT 611..649
FT /note="WD 3"
FT REPEAT 652..697
FT /note="WD 4"
FT REPEAT 701..742
FT /note="WD 5"
FT REPEAT 758..788
FT /note="WD 6"
FT REGION 1..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..78
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..102
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 788 AA; 88186 MW; 51BAD65906E06DAA CRC64;
MNASKASKKR KAVTRDVEEE AGVFSGDELN ADNLDGALSD NANDLSSDED DSDSEIELVD
EFSEDDEDDE ELDSDEIPSD GEDAVKKKSV TTTDKSGEIA EDAESSSEEE ELDFRIEKDA
NGNDRFIYDE INPDDNSEYS DVEENSNTIG DIPLSFYDQY PHIGYDINGK KILRPAKGEA
LDALLDSIEI PKGWTGLTDP STGKPLELSQ DELELLRKVQ MNEIPEEGYN PYEPTVEWFT
SQQEIMPLSA APEPKRRFVP SKHEAKRVMK IVKAIREGRI LPFKPPTEED KEEDNVINYD
LWADEAERPD HIMHIPAPKL PPPGYEESYH PPPEYLPDKK ERKAWEEADP EDREQEFLPN
DFGSLRRVPG YENFVKEKFE RCLDLYLAPR VRRSKLNIDP ESLLPKLPSP EELKPFPTAC
ATVFRGHKGR VRSLAVDPSG LWLATAGDDG TVRVWELLTG RQLWSVKLSE EDPVNVVRWR
PGKDALILAA AAGDDIYLAV PPIVDPEVEK ASLDILDAGW GHAASVPALT PAEANKKNNP
PKWIRPSSSL QESGVCAIIP LRYIAKSLSW HRRGDYFVTV CPGSSTPASV AIAIHTLSKH
LTQYPFRRRI KGGGSPQAAH FHPSKPILFV ANQRSIRAYD LSRQLLVKIL QPGARWISSF
DIHPTSSTAS GGDNLIVGSY DRRLLWHDLE LSQRPYKTLR YHRKAIRAVK FHPGGRYPLF
ADASDDGSLQ IFHGSVTGDM LSNATIVPLK VLKGHKITGE LGVLDIDWHP REPWCVSAGA
DGTCRLWM
