ERB1_ASPFC
ID ERB1_ASPFC Reviewed; 796 AA.
AC B0XQ42;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Ribosome biogenesis protein erb1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=erb1; ORFNames=AFUB_008620;
OS Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=451804;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of erb1, nop7 and
CC ytm1. The complex is held together by erb1, which interacts with nop7
CC via its N-terminal domain and with ytm1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; DS499594; EDP56156.1; -; Genomic_DNA.
DR AlphaFoldDB; B0XQ42; -.
DR SMR; B0XQ42; -.
DR EnsemblFungi; EDP56156; EDP56156; AFUB_008620.
DR VEuPathDB; FungiDB:AFUB_008620; -.
DR HOGENOM; CLU_011390_0_1_1; -.
DR PhylomeDB; B0XQ42; -.
DR Proteomes; UP000001699; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IEA:EnsemblFungi.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:EnsemblFungi.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Repeat; Ribosome biogenesis; rRNA processing; WD repeat.
FT CHAIN 1..796
FT /note="Ribosome biogenesis protein erb1"
FT /id="PRO_0000370417"
FT REPEAT 434..473
FT /note="WD 1"
FT REPEAT 477..517
FT /note="WD 2"
FT REPEAT 619..657
FT /note="WD 3"
FT REPEAT 660..705
FT /note="WD 4"
FT REPEAT 709..750
FT /note="WD 5"
FT REPEAT 766..796
FT /note="WD 6"
FT REGION 1..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..80
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..116
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..338
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..366
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 796 AA; 88988 MW; BC75A6A0BD5F0E11 CRC64;
MNTSKASKKR KAVTRDVEEE AGVFSGDELN TGNLDGALSD NAHDLSSDED ESDSEVELID
DFSDEEDEEE EDVLDSDEIP SDGEDSAKKK SNAAPGELGA VIDDDDDDDD DESPSEEEQL
NYRIEKDANG NDRFVYDEIN PDDNSDYSDV DENANTIGNI PLSFYDQYPH IGYDINGKKI
MRPAKGEALD ALLDSIEIPK GWTGLTDPST GKPLELSQEE LELLRKVQMN EIPEDGYNPY
EPIVEWFTSQ QEIMPLSAAP EPKRRFVPSK HEAKRVMKIV KAIREGRILP FKPPTEEDEE
DDTIVKYDLW ADEAERKDHP MHIPAPKLPP PGYEESYHPP PEYLPSRKER KTWEEADPED
RDREFLPNDF GSLRRVPGYE NFVKEKFERC LDLYLAPRVR RSKLNIDPES LLPKLPSPEE
LKPFPTACAT VFRGHKGRVR TLAVDPSGLW LASGGDDGTV RVWELLTGRQ LWSVKLSEED
PVNVVRWRPG KDALILAAAA GDDIFLAVPP IVDPAMEKAS LDILDAGWGY AASVPPPTPA
EANKKNNPPK WMRPSSSLAD SGVCAVIPLR YVAKSLSWHR RGDYFVTVCP GSSTPASVAI
AIHTLSKHLT QYPFRRRIKG GGPPQAAHFH PSKPILFVAN QRSIRAYDLS RQLLVKILQP
GARWISSFDI HPTSSTASGG DNLIVGSYDR RLLWHDLELS QRPYKTLRYH RKAIRAVKFH
PGGRYPLFAD ASDDGSLQIF HGSVTGDMLS NATIVPLKVL KGHKITGELG VLDVDWHPRE
PWCVSAGADG TCRLWM
