ERB1_ASPNC
ID ERB1_ASPNC Reviewed; 788 AA.
AC A2QPZ4;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Ribosome biogenesis protein erb1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=erb1; ORFNames=An08g00720;
OS Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=425011;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX PubMed=17259976; DOI=10.1038/nbt1282;
RA Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT niger CBS 513.88.";
RL Nat. Biotechnol. 25:221-231(2007).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of erb1, nop7 and
CC ytm1. The complex is held together by erb1, which interacts with nop7
CC via its N-terminal domain and with ytm1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; AM270157; CAK45224.1; -; Genomic_DNA.
DR RefSeq; XP_001392190.1; XM_001392153.1.
DR AlphaFoldDB; A2QPZ4; -.
DR SMR; A2QPZ4; -.
DR PaxDb; A2QPZ4; -.
DR EnsemblFungi; CAK45224; CAK45224; An08g00720.
DR GeneID; 4982386; -.
DR KEGG; ang:ANI_1_92074; -.
DR VEuPathDB; FungiDB:An08g00720; -.
DR HOGENOM; CLU_011390_0_1_1; -.
DR Proteomes; UP000006706; Chromosome 8R.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IEA:EnsemblFungi.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:EnsemblFungi.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..788
FT /note="Ribosome biogenesis protein erb1"
FT /id="PRO_0000370419"
FT REPEAT 426..465
FT /note="WD 1"
FT REPEAT 469..509
FT /note="WD 2"
FT REPEAT 611..649
FT /note="WD 3"
FT REPEAT 652..697
FT /note="WD 4"
FT REPEAT 701..742
FT /note="WD 5"
FT REPEAT 758..788
FT /note="WD 6"
FT REGION 1..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..78
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..330
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..354
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 788 AA; 87928 MW; AD141D63ABD337BC CRC64;
MSAAKVSKKR KAVTKDVEEE AGVFSGDELN VGDIDGALSD DANDLSSDEE DSEVELVDDF
SSDEDEDEEE ELDSDEIPSD GEAPLKKKSG TSAADLEVPT NDDESSSEEE QPNFRIEKDA
NGNDRYIYDE INPDDNSDYS DVEENANTIG NIPLSFYDQY PHIGYDINGK KIMRPATGEA
LDALLDSIEI PKGFTGLTDP STGKPLELSQ DELELLRKVQ MNEIPEEGYN PYEPLMEWFS
NKQEIMPLSA APEPKRRFVP SKHEAKRVMK IVKAIREGRI LPYKPPSEEK EEDLELINYD
LWADEAERPD HPMHVPAPKL PPPGYEESYH PPPEYLPDNK ERKAWQEADP EDREREYLPT
DFGSLRKVPG YGEFVKEKFE RCLDLYLAPR VRRSKLNIDP ESLLPKLPSP EELKPFPSVC
ATVFRGHKGR VRSLAVDPTG VWLATGGDDG TVRVWELLTG RQLYSVKVGE EDPVNVVRWR
PSKDAVVLAA AAGDDIYLIV PPILDPELEQ ASLDLLDAGW GYAASKPAPK ASEEGKKTTP
PQWVRPSAAL ADNGVCAVIP LRYVAKSISW HRRGDYFVTV CPGSSTPASM AIAIHTLSKH
LTQYPFSRRI KGGGPPQTAH FHPSKPILFV ANQRTVRAYD LSRQLLVKII QPGARWISSF
DIHPTSSTAS GGDNLIVGSY DRRLLWHDLE LSQRPYKTLR YHRKAIRAVK FHPSGRYPLF
ADASDDGSLQ IFHGSVTGDM LSNASIVPLK VLKGHKITGE LGVMDLDWHP REAWCVSAGA
DGTCRLWM
