ERB1_ASPOR
ID ERB1_ASPOR Reviewed; 783 AA.
AC Q2UPK0;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Ribosome biogenesis protein erb1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=erb1; ORFNames=AO090005001611;
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of erb1, nop7 and
CC ytm1. The complex is held together by erb1, which interacts with nop7
CC via its N-terminal domain and with ytm1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; AP007151; BAE56515.1; -; Genomic_DNA.
DR RefSeq; XP_001818517.2; XM_001818465.2.
DR AlphaFoldDB; Q2UPK0; -.
DR SMR; Q2UPK0; -.
DR STRING; 510516.Q2UPK0; -.
DR EnsemblFungi; BAE56515; BAE56515; AO090005001611.
DR GeneID; 5990462; -.
DR KEGG; aor:AO090005001611; -.
DR HOGENOM; CLU_011390_0_1_1; -.
DR OMA; MRPAKGE; -.
DR Proteomes; UP000006564; Chromosome 1.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IEA:EnsemblFungi.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:EnsemblFungi.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..783
FT /note="Ribosome biogenesis protein erb1"
FT /id="PRO_0000370420"
FT REPEAT 421..460
FT /note="WD 1"
FT REPEAT 464..504
FT /note="WD 2"
FT REPEAT 555..600
FT /note="WD 3"
FT REPEAT 606..644
FT /note="WD 4"
FT REPEAT 647..692
FT /note="WD 5"
FT REPEAT 696..737
FT /note="WD 6"
FT REPEAT 753..783
FT /note="WD 7"
FT REGION 1..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..80
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..325
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 783 AA; 87651 MW; 38DD13BB441E1FDB CRC64;
MDASKSSKKR KAVTRDVEEE AGVFSGDELQ VDVLDGALSD NANDLSSDED VSDSEIELVD
DFSDEEDGDE EEELDSDEIP SDGGESFKKA SGTGNARDES SSDEEQLNYR IEKDANGNDR
YVYDEINPDD NSDYSDVEEN ANTIGNIPLS FYDQYPHIGY DINGKKIMRP ATGEALDALL
DSIEIPKGWT GLTDPSTGKP LELSQDELEL LRKVQMNEIP EEGYNPYEPT VEWFSSKQEI
MPLSAAPEPK RRFVPSKHEA KRVMKIVKAI REGRILPYKP PTEEEDKEQD VVNYDLWADE
TERPDHPMHI PAPKLPPPGY EESYHPPPEY LPDKKERKAW EEADPEDRER EYLPNDFGSL
RKVPGYESFV KEKFERCLDL YLAPRVRRSK LNIDPESLLP KLPSPEELKP FPTACATVFR
GHKGRVRTLA VDPSGLWLAT GGDDGTARVW ELLTGRQLWS VKLSEEDPVN VVRWRPGKDA
VILAAAAGDD IFLAVPPIAD PKIEKTSLEI IDAGWGYAAS KPPPSAAEEN KKNVPPQWIR
PSLSLAESGV CAVIPLRYVV KSLSWHRRGD YFVTVCPGSS TPASVAISIH TLSKHLTQFP
FRRRIKGGGP PQTAHFHPSK PILFVANQRT IRAYDLSRQL LVKIIQPGAR WISSFDIHPT
SSTASGGDNL IVGSYDRRLL WHDLELSQRP YKTLRYHRKA IRSVRFHPSG RYPLFADASD
DGSLQIFHGS VTGDMLSNAS IVPLKVLKGH KITGELGVLD VDWHPREAWC VSAGADGTCR
LWM
