ERB1_ASPTN
ID ERB1_ASPTN Reviewed; 784 AA.
AC Q0CCP0;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Ribosome biogenesis protein erb1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=erb1; ORFNames=ATEG_08544;
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156;
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of erb1, nop7 and
CC ytm1. The complex is held together by erb1, which interacts with nop7
CC via its N-terminal domain and with ytm1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; CH476606; EAU30676.1; -; Genomic_DNA.
DR RefSeq; XP_001217130.1; XM_001217129.1.
DR AlphaFoldDB; Q0CCP0; -.
DR SMR; Q0CCP0; -.
DR STRING; 341663.Q0CCP0; -.
DR EnsemblFungi; EAU30676; EAU30676; ATEG_08544.
DR GeneID; 4323512; -.
DR VEuPathDB; FungiDB:ATEG_08544; -.
DR eggNOG; KOG0650; Eukaryota.
DR HOGENOM; CLU_011390_0_1_1; -.
DR OMA; MRPAKGE; -.
DR OrthoDB; 759498at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IEA:EnsemblFungi.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:EnsemblFungi.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..784
FT /note="Ribosome biogenesis protein erb1"
FT /id="PRO_0000370421"
FT REPEAT 422..461
FT /note="WD 1"
FT REPEAT 465..505
FT /note="WD 2"
FT REPEAT 607..645
FT /note="WD 3"
FT REPEAT 648..693
FT /note="WD 4"
FT REPEAT 697..738
FT /note="WD 5"
FT REPEAT 754..784
FT /note="WD 6"
FT REGION 1..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..78
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..326
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 784 AA; 87793 MW; F2F6C87B34FA13A6 CRC64;
MVNASKVSKK RKAVTRDVEE EAGVFSGDEL NAENLDGALS DNANELSSDE DDSEVELVDE
FSDEDDEDEE ELDSDEIPSD GEEPKKKSAS TAVDGPQADD ESSSEDEQPN FRIEKDANGE
DRYIYDEINP DDNSDYSDVD ENANTIGNIP LKFYDEYPHI GYDINGKKIM RPAKGEALDA
LLDSIEIPKG WTGLTDPSTG KPLELSQDEL ELLRKVQMNE IPEEGYDPYE PLMEWFSNKQ
EIMPLSAAPE PKRRFVPSKH EAKRVMKIVK AIKEGRILPY KPPTEEDEDK DVINYDLWAD
EAERPDHPMH VPAPKLPPPG YEESYHPPPE YLPDKKERKA WEETDPEDRE QEFLPNDFGS
LRKVPGYENF VKEKFERCLD LYLAPRVRRS KLNIDPESLL PKLPSPEELK PFPTTCATVF
RGHKGRVRTV SVDPSGVWLA TGGDDGTLRV WELLTGRQLW TVKLSDEDAV NVVRWRPGKD
AVVLAAGVGD DIFLAVPPIV DPELEKASLE LIDAGWGYAA SRPPPTAAEE NKKNTPPQWI
RPSAALADSG VCAVIPLRYV VKTLSWHRRG DYFVTVCPGS STPASVAISI HTLSKHLTQF
PFRKRIKGGG PPQTAHFHPS KPILFVANQR TIRAYDLSRQ LLVKIVQPGA RWISSFDIHP
TSSTAAGGDN IIVGSYDRRL LWHDLELSQR PYKTLRYHRK AIRSVKFHPG GRYPLFADAS
DDGSLQIFHG SVTGDMLSNA SIVPLKVLKG HKITGELGVL DVDWHPREAW CVSAGADGTC
RLWM
