ERB1_BOTFB
ID ERB1_BOTFB Reviewed; 763 AA.
AC A6RRD4;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Ribosome biogenesis protein erb1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=erb1; ORFNames=BC1G_03375;
OS Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis
OS cinerea).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Botrytis.
OX NCBI_TaxID=332648;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B05.10;
RX PubMed=21876677; DOI=10.1371/journal.pgen.1002230;
RA Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A.,
RA Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M.,
RA Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C.,
RA Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.;
RT "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT sclerotiorum and Botrytis cinerea.";
RL PLoS Genet. 7:E1002230-E1002230(2011).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of erb1, nop7 and
CC ytm1. The complex is held together by erb1, which interacts with nop7
CC via its N-terminal domain and with ytm1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; CH476851; EDN18091.1; -; Genomic_DNA.
DR RefSeq; XP_001558526.1; XM_001558476.1.
DR AlphaFoldDB; A6RRD4; -.
DR SMR; A6RRD4; -.
DR GeneID; 5439141; -.
DR KEGG; bfu:BCIN_11g04150; -.
DR VEuPathDB; FungiDB:Bcin11g04150; -.
DR OMA; MRPAKGE; -.
DR OrthoDB; 759498at2759; -.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IEA:EnsemblFungi.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:EnsemblFungi.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Nucleus; Repeat; Ribosome biogenesis; rRNA processing; WD repeat.
FT CHAIN 1..763
FT /note="Ribosome biogenesis protein erb1"
FT /id="PRO_0000370422"
FT REPEAT 414..453
FT /note="WD 1"
FT REPEAT 457..497
FT /note="WD 2"
FT REPEAT 593..633
FT /note="WD 3"
FT REPEAT 634..673
FT /note="WD 4"
FT REPEAT 677..717
FT /note="WD 5"
FT REPEAT 733..763
FT /note="WD 6"
FT REGION 1..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..76
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..341
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 763 AA; 85812 MW; FA988256A25BBF3C CRC64;
MAPPTNQRKR KAVTRDEPEI SDVESEAEFG DGILEGILSQ SEDESDDSAA EEDSEDEEDL
DEEELEALDS DEVPSENGEG EGSMTRTSLN KINADEDDDK PNYTVVKDAN GGERYVYEEI
NPVYDSDDSD AQEPTNTIGN IPLSFYDSYP HIGYDINGKK IMRPAKGEAL DALLDSIDIP
KGWTGLTDPS TGKPLNLTQE ELEVLRRIQT NEVPEDGYDP YPDYVPYFSG VEEIMPLSSA
PEPKRRFLPS KHEAKRIMKI VRAIREGRIL PYKPPQEREE EEEEHHYDIW QNEEAQPDHI
MKIPAPKPPP PGYDLSYNPP PEYLPSKAER KEWEATDPED REKEYLPTAY DSLRKVPGYD
KFINERFERS LDLYLAPRVR KNRLNIDPAS LLPKLPKPEE LKPFPTVTQT LFRGHDGRVR
SLAIDPSGTW LATGGDDGTV RVWELLTGKQ LWSAQIGDEE AVNVVKWRPA KDAIILSAAA
GDDIFLMVPT IIDPVAESNS RELLDAGFGY ATNATQALTA NGQKKEPVAT WARPTSRLQD
EGVLIKITVR STVKVINWHR RGDFFSTVSP TAQKSAVAIH TLSKHLTQIP FRRLPGIAQT
AQFHPSRPIF FVATQRTIRS YDLQKQELVK IIQPGARWIS SFDIHPGGDN LIVGSYDRRL
LWHDLDLSTR PYKTMRFHNK AIRAVKYHKG GLPLFADASD DGSLQIFHGK VVSDAMENAT
IVPVKVLKGH KVKSALGVMD LDWHPKEPWL VSAGADGTCR LWT
