ERB1_CANAL
ID ERB1_CANAL Reviewed; 849 AA.
AC Q59VP7; A0A1D8PD96;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN OrderedLocusNames=CAALFM_C104130WA; ORFNames=CaO19.1047, CaO19.8649;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; CP017623; AOW26088.1; -; Genomic_DNA.
DR RefSeq; XP_713651.2; XM_708558.2.
DR AlphaFoldDB; Q59VP7; -.
DR SMR; Q59VP7; -.
DR BioGRID; 1227765; 2.
DR STRING; 237561.Q59VP7; -.
DR PRIDE; Q59VP7; -.
DR GeneID; 3644702; -.
DR KEGG; cal:CAALFM_C104130WA; -.
DR CGD; CAL0000194713; ERB1.
DR VEuPathDB; FungiDB:C1_04130W_A; -.
DR eggNOG; KOG0650; Eukaryota.
DR HOGENOM; CLU_011390_0_1_1; -.
DR InParanoid; Q59VP7; -.
DR OMA; MRPAKGE; -.
DR OrthoDB; 759498at2759; -.
DR PRO; PR:Q59VP7; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IBA:GO_Central.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IBA:GO_Central.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..849
FT /note="Ribosome biogenesis protein ERB1"
FT /id="PRO_0000370423"
FT REPEAT 457..496
FT /note="WD 1"
FT REPEAT 505..545
FT /note="WD 2"
FT REPEAT 633..675
FT /note="WD 3"
FT REPEAT 678..716
FT /note="WD 4"
FT REPEAT 719..758
FT /note="WD 5"
FT REPEAT 762..802
FT /note="WD 6"
FT REPEAT 818..849
FT /note="WD 7"
FT REGION 1..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..405
FT /note="Required for interaction with NOP7"
FT /evidence="ECO:0000250"
FT REGION 405..441
FT /note="Required for interaction with YTM1"
FT /evidence="ECO:0000250"
FT REGION 569..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..120
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 579..603
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 849 AA; 97380 MW; 0E9ED90DF8D4E691 CRC64;
MARNSIKKSP VVKKKDTPIV RKRKPIQQEA EEDSNDEESE DELNVEGLID ASDDEDEEEE
QEQEEQPQEE ENNSDDDDDD DDDDDDNNSE ADSEEELNQL LGEEEEEDPS DYNSDEFSDE
PKDDDLSRIN IKSLSVSDPS IQKNSISKFS DGSIRILKPE IEPKYDSDDS DAENFNTIGN
IPISAYDEMP HIGYDINGKR IMRPAKGSAL DQLLESIDLP EGWTGLLDQN TGTSLKLTDE
ELELIRKIQQ QENTDENINP YEPLIDWFTK DEEIMPVTAV PEPKRRFVPS KHEAKRVMKI
VKAIREGRII PPNKVKQQLT EEEEEDQFNF DLWQDEIEIS DHIMNLRAPK LPPPTNEESY
NPPEEYLLTE EEKSKWLQES PIDRERNFLP QKYNSLRQVP GYQDSVRERF ERSLDLYLAP
RVRHNKLNID PDSLIPDLPS PKDLRPFPIR CSTIYEGHTG KIRTISIDPQ GLWLATGSDD
GSVRIWEILT GRQVYKIQLI NKEINNEDHI ECLEWNPDSS CGILAVCVGE NIYLIVPPIF
GFDIENSGKL RIESGWGYDT FGNKKKDLKI SSQKEEDNKE SDNEDEDEEE DNDDDDDDDE
PETSSTVEPK KEVAKWYPPN TEQASMGISA IIQCRKTIKK LSWHRKGDYF VTVSPDSKNT
AVLIHQISKH LSQSPFKKSK GIIMDAKFHP FKPQLFVASQ RQIKIYDLAQ QVLLKKLMPG
VRLLSTIDIH PRGDNLIAGS YDKRVLWHDL DLSATPYKTL RYHEKAVRSI KFHKGNLPLF
ASASDDGNIH IFHGTVYDDL MTNPLLVPLK KLNGHKIINQ IGILDLIWHP KEPWLFSAGA
DGTARLWTT
