ERB1_CANGA
ID ERB1_CANGA Reviewed; 805 AA.
AC Q6FLA4;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN OrderedLocusNames=CAGL0L04950g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; CR380958; CAG61960.1; -; Genomic_DNA.
DR RefSeq; XP_448990.1; XM_448990.1.
DR AlphaFoldDB; Q6FLA4; -.
DR SMR; Q6FLA4; -.
DR STRING; 5478.XP_448990.1; -.
DR EnsemblFungi; CAG61960; CAG61960; CAGL0L04950g.
DR GeneID; 2890714; -.
DR KEGG; cgr:CAGL0L04950g; -.
DR CGD; CAL0135218; CAGL0L04950g.
DR VEuPathDB; FungiDB:CAGL0L04950g; -.
DR eggNOG; KOG0650; Eukaryota.
DR HOGENOM; CLU_011390_0_1_1; -.
DR InParanoid; Q6FLA4; -.
DR OMA; MRPAKGE; -.
DR Proteomes; UP000002428; Chromosome L.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IEA:EnsemblFungi.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:EnsemblFungi.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..805
FT /note="Ribosome biogenesis protein ERB1"
FT /id="PRO_0000370424"
FT REPEAT 434..473
FT /note="WD 1"
FT REPEAT 482..522
FT /note="WD 2"
FT REPEAT 590..632
FT /note="WD 3"
FT REPEAT 635..673
FT /note="WD 4"
FT REPEAT 676..715
FT /note="WD 5"
FT REPEAT 719..758
FT /note="WD 6"
FT REPEAT 775..805
FT /note="WD 7"
FT REGION 1..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..382
FT /note="Required for interaction with NOP7"
FT /evidence="ECO:0000250"
FT REGION 382..418
FT /note="Required for interaction with YTM1"
FT /evidence="ECO:0000250"
FT COMPBIAS 1..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..78
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 805 AA; 91655 MW; 2A58BACD7AE5DEB2 CRC64;
MVKGRKSQKA DKVTKAKKRV ADEVDESESE PELQVEGLID AEAESEDDES FESAEENASA
EEDEEDEEDE EDSDAELNKL LAEEEGDDSE SEYNTSDFSE DDTKSMTDKL SGVKLTTIAE
PIIKTKFSDG TPRVIKPEIN PVYDSDDSDI ESKNTIGNIP LSVYDEMPHI GYDVNGKRIM
RPARASALDQ LLDTIELPEG WTGLLDKESG ASLNISKEEL ELISKIQRNE QTDESTNPYE
PLIDWFTRHE EVMPLSAAPE PKRRFVPSKN EAKRIMKIVK AIREGRIIPP KKMKELREKE
KSEDFNYDLW GDSTETNDHI MNLRAPKLPP PTNEESYNPP AEYLPTEEEI KEWENTEYSE
RERNFVPKKY DSLRKVPGYT ESVRERFERS LDLYLAPRMR KNKLNIDPES LIPELPSPKD
LRPFPIRCST IYSGHEGKIR TLSIDPTGIW LATGSDDGSV RIWEILTGRE VYRVQLVNKE
DNPEDNIHSV EWNPDGSVGI LAVAVGNNIF LIVPPIFGYD IENAGKVRIE HGFGYDTFGS
TKKANLEVNG SDLESDDEAA NANTAVKKQV AQWHKPTQRQ MEQDICIVIV CKKPVKKLSW
HRKGDYFVTV QPDSGNTSVL IHQLSKHLTQ SPFRKSKGII MDAKFHPFKP QLFVCSQRYV
RIYDLSQQVL VKKLLPGARW LSNIDIHPRG DNLIASSYDK RVLWHDLDLA ATPYKTLRYH
DKAVRSTTFH KKLPLFCSAA DDGFIHIFHA TVYDDMMKNP MIVPLKKLTG HKVQGHLGVL
DTIWHPKEAW LFSAGADNTA RMWTT
