ERB1_CHAGB
ID ERB1_CHAGB Reviewed; 782 AA.
AC Q2HDW0;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=ERB1 {ECO:0000255|HAMAP-Rule:MF_03027}; ORFNames=CHGG_01594;
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; CH408029; EAQ93359.1; -; Genomic_DNA.
DR RefSeq; XP_001220815.1; XM_001220814.1.
DR AlphaFoldDB; Q2HDW0; -.
DR SMR; Q2HDW0; -.
DR STRING; 38033.XP_001220815.1; -.
DR EnsemblFungi; EAQ93359; EAQ93359; CHGG_01594.
DR GeneID; 4386342; -.
DR eggNOG; KOG0650; Eukaryota.
DR HOGENOM; CLU_011390_0_1_1; -.
DR InParanoid; Q2HDW0; -.
DR OMA; MRPAKGE; -.
DR OrthoDB; 759498at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..782
FT /note="Ribosome biogenesis protein ERB1"
FT /id="PRO_0000370425"
FT REPEAT 433..472
FT /note="WD 1"
FT REPEAT 476..516
FT /note="WD 2"
FT REPEAT 567..609
FT /note="WD 3"
FT REPEAT 612..650
FT /note="WD 4"
FT REPEAT 653..692
FT /note="WD 5"
FT REPEAT 696..736
FT /note="WD 6"
FT REPEAT 752..782
FT /note="WD 7"
FT REGION 1..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..82
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..123
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 782 AA; 87999 MW; 9FF2A4B9A20735DB CRC64;
MGSKITDKKR KSRDSESESD DELANGLFDG ILSQSEDEED YLPSDDDDDV EDSENEGTGA
SEDDDDDDDD DDILSDDIPS DVDSEEAINR LVKQQEELEI TEPGVDPKRE EDDGADRNYR
IEKDANGGER YVYDEIDPVY DSDDSDAKGP VNTIGDIPLS FYDSYPHIGY DINGKKIMRP
ATGDALQSLL DSIEVPKGWT GLTDVDTGNP LNLTQDELEL VRRVQMGLLP TDLQDPYPDT
VEYFTSIEEK MPLSSAPEPK RRFLPSKNEA KQIMKLVRAI REGRILPYKP PEEREREEEE
QEEVHFDLWQ NEEPQAPNPM HIPAPKLAPP GYDLSYNPPE EYLPSKEERE EWENADPEDR
EKEYLPQKHN ALRKVPAWGN LVKERFERCM DLYLAPRIRK NRLNIDPNSL LPKLPSPSEL
KPFPTVAQTI FRGHEGRVRS VSVDPTGVAL ATGGDDGTVR VWELLTGRQV WSVKLNSEEP
VNAVRWRPTK DAFVLAAAAG EDIFLMVPTH ASVTPALDQA SRDILATGFG YATNGQQPAA
PVSKEPAAKW ARPGTKLEDE GVLIRITVRS TVKVINWHRR GDHFATVSPT GQRSSVAIHT
LSKHLTQIPF RKLSGLAQTA AFHPLRPLFF VATQRTIRCY DLQKLELVKV VQPGAKWISS
FDIHPGGDNL IVGSYDKRLL WHDLDLSNRP YKTMRFHGQA IRQVRYHRGG LPLFADASDD
GSLQIFHGKV PNDQLENPTI VPVKMLKGHK VVSKLGVLDI DWHPREPWCV SAGADGTARL
WM
