ID   ERB1_COPC7              Reviewed;         751 AA.
AC   A8NWR2;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE   AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN   Name=ERB1 {ECO:0000255|HAMAP-Rule:MF_03027}; ORFNames=CC1G_00099;
OS   Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
OS   (Inky cap fungus) (Hormographiella aspergillata).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Psathyrellaceae; Coprinopsis.
OX   NCBI_TaxID=240176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003;
RX   PubMed=20547848; DOI=10.1073/pnas.1003391107;
RA   Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M.,
RA   Burns C., Canbaeck B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S.,
RA   Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.,
RA   Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C.,
RA   Kuees U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.-J.,
RA   Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O.,
RA   Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M.,
RA   Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q.,
RA   Zolan M.E., Pukkila P.J.;
RT   "Insights into evolution of multicellular fungi from the assembled
RT   chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010).
CC   -!- FUNCTION: Component of the NOP7 complex, which is required for
CC       maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC       YTM1. The complex is held together by ERB1, which interacts with NOP7
CC       via its N-terminal domain and with YTM1 via a high-affinity interaction
CC       between the seven-bladed beta-propeller domains of the 2 proteins. The
CC       NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC       Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAU84580.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AACS02000005; EAU84580.2; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001836963.2; XM_001836911.2.
DR   AlphaFoldDB; A8NWR2; -.
DR   SMR; A8NWR2; -.
DR   STRING; 5346.XP_001836963.2; -.
DR   EnsemblFungi; EAU84580; EAU84580; CC1G_00099.
DR   GeneID; 6013517; -.
DR   KEGG; cci:CC1G_00099; -.
DR   eggNOG; KOG0650; Eukaryota.
DR   HOGENOM; CLU_011390_0_1_1; -.
DR   InParanoid; A8NWR2; -.
DR   OrthoDB; 759498at2759; -.
DR   Proteomes; UP000001861; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..751
FT                   /note="Ribosome biogenesis protein ERB1"
FT                   /id="PRO_0000370427"
FT   REPEAT          410..449
FT                   /note="WD 1"
FT   REPEAT          536..580
FT                   /note="WD 2"
FT   REPEAT          582..621
FT                   /note="WD 3"
FT   REPEAT          622..661
FT                   /note="WD 4"
FT   REPEAT          665..704
FT                   /note="WD 5"
FT   REPEAT          720..751
FT                   /note="WD 6"
FT   REGION          1..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          289..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..92
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        319..336
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   751 AA;  85440 MW;  C76ABD382C899312 CRC64;
     MALTDSKKKA TSKRKRDEPE QEQTHTLTSQ LEMLTDEEGD DDNAGDVSDD GEYDEFPEID
     AESDSEEEDE EEDEEDEEDE PDISDEEDSD SDESLHVFPK AKTVVSDITG QQKRVYPEIE
     PDYDSDSSTE DSPNRVGNVP MHWYDDLPHI GYDINGKRVL RPAKGDELDK FLATIEDPDS
     WTSAFDKKMQ MDKPLTSEEL DIIQRLYAGE NPDATYDPYE PMVEWFTGKG KEEIMPLSAA
     PEPKRRWVRS KWEKQKIMKI VRAIRQGRIV PNKPKTSSKQ FEFYSIWSSE PSSSQPPPLP
     APKRPLPTNA ESYNPPEEYL PTEEEKQEWL KQDPEDRERD FLPQKFSSLR HVPAYDQFIK
     ERFNRQLDLY LAPRIQRVKL NIDPNSLIPK LPSPSSLKPF PNYRSLLFTH PKGRARCVSV
     SPDGAWAVSG DEDGVVSLWE VNVGCEIRRW KFEGKIGSLE WCPRADACYF AVGIEETIHF
     LIPPNLDPTV LALTQTLLAP STLPPAPATP SAVKWSSSSL SSWSVEQPIL SLNLPPSSGL
     PTQISWHKKG DYIATVSSGG AQNGVWIHQF TRRHSQAPFK KIKGAVQQVL FHPIKPHFFV
     ATQQYVRLYN LAEQKLIKTL QPGIRWISSM DVHPSGDHVI VGGYDRKLCW FDLELSEKPY
     KVLRYHSRAI RSLHFHPTYP LFASSSDDGS IQIFHARVYN DLMTDPLIVP LKILRGHQIT
     DGLGILQVKW TPKHPWLLSA AADGTVAVWC S