ERB1_CRYNB
ID ERB1_CRYNB Reviewed; 830 AA.
AC P0CS35; Q55YA2; Q5KLN6;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 50.
DE RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=ERB1 {ECO:0000255|HAMAP-Rule:MF_03027}; OrderedLocusNames=CNBB1130;
OS Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=283643;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B-3501A;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; AAEY01000007; EAL22664.1; -; Genomic_DNA.
DR RefSeq; XP_777311.1; XM_772218.1.
DR AlphaFoldDB; P0CS35; -.
DR SMR; P0CS35; -.
DR EnsemblFungi; EAL22664; EAL22664; CNBB1130.
DR GeneID; 4934203; -.
DR KEGG; cnb:CNBB1130; -.
DR VEuPathDB; FungiDB:CNBB1130; -.
DR HOGENOM; CLU_011390_0_1_1; -.
DR Proteomes; UP000001435; Chromosome 2.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IEA:EnsemblFungi.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:EnsemblFungi.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Nucleus; Repeat; Ribosome biogenesis; rRNA processing; WD repeat.
FT CHAIN 1..830
FT /note="Ribosome biogenesis protein ERB1"
FT /id="PRO_0000410330"
FT REPEAT 481..520
FT /note="WD 1"
FT REPEAT 523..563
FT /note="WD 2"
FT REPEAT 660..698
FT /note="WD 3"
FT REPEAT 701..740
FT /note="WD 4"
FT REPEAT 744..783
FT /note="WD 5"
FT REPEAT 799..830
FT /note="WD 6"
FT REGION 1..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..112
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 830 AA; 93538 MW; 3B5022C799F39516 CRC64;
MAPQPLKVGT SKLSKMVKSA PKTAGKSKKR AVEQVSEESD EEFGDQGSGI DMSDDEEEVD
GDDEEDEDEA FPEFDSELED NDQEEASDEE QDEQDTSDES EIVEEDSDSE SGYNTSDIER
MYASDDDLSS EENKDLPVDE KLSRLIAKNT VKPDDSIGTD DKISRAKEGV GRLVPSKHVK
GSFVREYDEY EAGYGSESST EDNPNTVGNI PMEWYDDLPH IGYDVNGRKI FRPLQGDELD
KFLANVEDPS AWTSAEDKLL QQNVQLSDKE LDIIRRLERA ENPDADFDPY QPTIEWFTGE
GKERVMPLSA APEPKRRFVP SKWEHKKIMK IVKAIREGRI IPNKPSAEKP RFYPIWSDAD
QHNPHVMYMP APQLPPPKTA ESYNPPEEYL PTEEEKAEWE AMDKEDRKTD FLPEKYDALR
KVPGYKNLVQ EKFERCLDLY LAPRTRRVKL NIDPDSLIPK LPAPKELKPF PIASTVQYRH
PGDTRVRSVS TSPDGQWIAS GSEDGVVRVW DLGNGREVWR WDLHAGPIQY VEWSPSREES
LLVALVAGKI AVLSPLALVA PHIAAQTLTH SNTAFATSSA TTKQGAGNEV KGIESVKWTR
PSERERERGV LVYVEVPGTP KQVTWHRKGD YFATVASDAA NKSVLIHQLS RHGSQSPFRK
TPGTIQRVAF HPSKPHFFAA TQRYIRLYDL AAQKLIRTLQ SGVKWISSMD VHSGGDNLII
GSYDKKLAWF DMDLSAKPYK TLRYHNRALR SVAYHPTLPL FASASDDGTV HIFHCTVYTD
LMQNPLIVPL KILRGHKVID GIGVLDLRWV PGKPWLVSSG ADGEVRLWCS
