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ERB1_CRYNJ
ID   ERB1_CRYNJ              Reviewed;         830 AA.
AC   P0CS34; Q55YA2; Q5KLN6;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE   AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN   Name=ERB1 {ECO:0000255|HAMAP-Rule:MF_03027}; OrderedLocusNames=CNB04640;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Component of the NOP7 complex, which is required for
CC       maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC       YTM1. The complex is held together by ERB1, which interacts with NOP7
CC       via its N-terminal domain and with YTM1 via a high-affinity interaction
CC       between the seven-bladed beta-propeller domains of the 2 proteins. The
CC       NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC       Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR   EMBL; AE017342; AAW41647.1; -; Genomic_DNA.
DR   RefSeq; XP_568954.1; XM_568954.1.
DR   AlphaFoldDB; P0CS34; -.
DR   SMR; P0CS34; -.
DR   STRING; 5207.AAW41647; -.
DR   PaxDb; P0CS34; -.
DR   EnsemblFungi; AAW41647; AAW41647; CNB04640.
DR   GeneID; 3256036; -.
DR   KEGG; cne:CNB04640; -.
DR   VEuPathDB; FungiDB:CNB04640; -.
DR   eggNOG; KOG0650; Eukaryota.
DR   HOGENOM; CLU_011390_0_1_1; -.
DR   InParanoid; P0CS34; -.
DR   OMA; MRPAKGE; -.
DR   OrthoDB; 759498at2759; -.
DR   Proteomes; UP000002149; Chromosome 2.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; IBA:GO_Central.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IBA:GO_Central.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..830
FT                   /note="Ribosome biogenesis protein ERB1"
FT                   /id="PRO_0000370428"
FT   REPEAT          481..520
FT                   /note="WD 1"
FT   REPEAT          523..563
FT                   /note="WD 2"
FT   REPEAT          660..698
FT                   /note="WD 3"
FT   REPEAT          701..740
FT                   /note="WD 4"
FT   REPEAT          744..783
FT                   /note="WD 5"
FT   REPEAT          799..830
FT                   /note="WD 6"
FT   REGION          1..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..112
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..142
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   830 AA;  93522 MW;  E0D8ACB3020D605F CRC64;
     MAPQPLKVGT SKLSKMVKSA PKTAGKAKKR AVEQVSEESD EEFGDQGSGI DMSDDEEEVD
     GDDEEDEDEA FPEFDSELED NDQEEASDEE QDEQDTSDES EIVEEDSDSE SGYNTSDIER
     MYASDDDLSS EENKDLPVDE KLSRLIAKNT VKPDDSIGTD DKISRAKEGV GRLVPSKHVK
     GSFVREYDEY EAGYGSESST EDNPNTVGNI PMEWYDDLPH IGYDVNGRKI FRPLQGDELD
     KFLANVEDPS AWTSAEDKLL QQNVQLSDKE LDIIRRLERA ENPDADFDPY QPTIEWFTGE
     GKERVMPLSA APEPKRRFVP SKWEHKKIMK IVKAIREGRI IPNKPSAEKP RFYPIWSDAD
     QHNPHVMYMP APQLPPPKTA ESYNPPEEYL PTEEEKAEWE AMDKEDRKTD FLPEKYDALR
     KVPGYKNLVQ EKFERCLDLY LAPRTRRVKL NIDPDSLIPK LPAPKELKPF PIASTVQYRH
     PGDTRVRSVS TSPDGQWIAS GSEDGVVRVW DLGNGREVWR WDLHAGPIQY VEWSPSREES
     LLVALVAGKI AVLSPLALVA PHIAAQTLTH SNTAFATSSA TTKQGAGNEV KGIESVKWTR
     PSERERERGV LVYVEVPGTP KQVTWHRKGD YFATVASDAA NKSVLIHQLS RHGSQSPFRK
     TPGTIQRVAF HPSKPHFFAA TQRYIRLYDL AAQKLIRTLQ SGVKWISSMD VHSGGDNLII
     GSYDKKLAWF DMDLSAKPYK TLRYHNRALR SVAYHPTLPL FASASDDGTV HIFHCTVYTD
     LMQNPLIVPL KILRGHKVID GIGVLDLRWV PGKPWLVSSG ADGEVRLWCS
 
 
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