ERB1_DEBHA
ID ERB1_DEBHA Reviewed; 811 AA.
AC Q6BRG6;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN OrderedLocusNames=DEHA2D16522g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; CR382136; CAG87375.2; -; Genomic_DNA.
DR RefSeq; XP_459204.2; XM_459204.1.
DR AlphaFoldDB; Q6BRG6; -.
DR SMR; Q6BRG6; -.
DR STRING; 4959.XP_459204.2; -.
DR PRIDE; Q6BRG6; -.
DR EnsemblFungi; CAG87375; CAG87375; DEHA2D16522g.
DR GeneID; 2901418; -.
DR KEGG; dha:DEHA2D16522g; -.
DR VEuPathDB; FungiDB:DEHA2D16522g; -.
DR eggNOG; KOG0650; Eukaryota.
DR HOGENOM; CLU_011390_0_1_1; -.
DR InParanoid; Q6BRG6; -.
DR OMA; MRPAKGE; -.
DR OrthoDB; 759498at2759; -.
DR Proteomes; UP000000599; Chromosome D.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..811
FT /note="Ribosome biogenesis protein ERB1"
FT /id="PRO_0000370429"
FT REPEAT 438..477
FT /note="WD 1"
FT REPEAT 485..525
FT /note="WD 2"
FT REPEAT 595..637
FT /note="WD 3"
FT REPEAT 640..678
FT /note="WD 4"
FT REPEAT 681..720
FT /note="WD 5"
FT REPEAT 724..764
FT /note="WD 6"
FT REPEAT 780..811
FT /note="WD 7"
FT REGION 1..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..386
FT /note="Required for interaction with NOP7"
FT /evidence="ECO:0000250"
FT REGION 386..422
FT /note="Required for interaction with YTM1"
FT /evidence="ECO:0000250"
FT REGION 547..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..98
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..566
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 811 AA; 92524 MW; A2B9EE76560A0BC4 CRC64;
MARNSKATDT PKTVVEKQSR KRKQDVEDAE ESSSDEELQV EGILDDAASE DEESDSEDAD
KEDDEEEELE GDSDEEFNEL LGEEEDLSDV DSEEFSDEPR DETASITDKL SGTKIRSYSN
ATEDEENEVH TKFSDGRPRI IKPEINPIYD SDDSDNENFN TIGNIPLSAY EEMPHIGYDI
NGKRIMRPAK GSALDQLLES IDLPEGWTGL FDQNTGTSLK ITDDELELIR KIQAQESTDE
NINPYEPTIE WFTSKTEVMP LTAVPEPKRR FVPSKHEAKK VMKIVRAIRE GRIVPPNKVK
EQQEEEKYNF DLWNDNESET KDHIMNLRAP KLPPPTNEES YNPPEEYLMD EEEKKKWLEM
EPEDRDKNYI PQKYNSLRKV PGYQEGLRER FERCLDLYLA PRTRHNKLNI DPDSLIPELP
SPKDLRPFPI RCSTIFQGHT EKIRTLSISP DGLWLATGSD DGSVRIWEIL TGRQVYKTVL
VADDNTDDNI ESLEWNPDSN SGILAAIAGE HIYLIVPPIF GFDIENNGRL RIESGWGYDT
FGNKSKTKNS NIKVNSDDED EEVEKADTNT GKKDVCKWFT PNTEQSQAGI SAIIQCRKTV
KKISWHRKGD YFVTVSPDSG HSSVLIHQLS KHLSQSPFKK SKGIIMDAKF HPFKPQLFVA
SQRYIRIYDL AQQVLVKKLM PGARWLSNID IHPRGDNLLA SSYDKRVLWH DLDLSSTPYK
TLRYHDKAVR SIKFHKANLP LFASASDDGS IHVFHGTVYD DLMTNPLLVP LKKLTGHKII
NSLGVLDLVW HPKEAWLFSA GADGTARLWT T
