ID   ERB1_KLULA              Reviewed;         791 AA.
AC   Q6CIH3;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE   AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN   Name=ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN   OrderedLocusNames=KLLA0F26653g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the NOP7 complex, which is required for
CC       maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC       YTM1. The complex is held together by ERB1, which interacts with NOP7
CC       via its N-terminal domain and with YTM1 via a high-affinity interaction
CC       between the seven-bladed beta-propeller domains of the 2 proteins. The
CC       NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC       Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR   EMBL; CR382126; CAG98974.1; -; Genomic_DNA.
DR   RefSeq; XP_456266.1; XM_456266.1.
DR   AlphaFoldDB; Q6CIH3; -.
DR   SMR; Q6CIH3; -.
DR   STRING; 28985.XP_456266.1; -.
DR   PRIDE; Q6CIH3; -.
DR   EnsemblFungi; CAG98974; CAG98974; KLLA0_F26653g.
DR   GeneID; 2894861; -.
DR   KEGG; kla:KLLA0_F26653g; -.
DR   eggNOG; KOG0650; Eukaryota.
DR   HOGENOM; CLU_011390_0_1_1; -.
DR   InParanoid; Q6CIH3; -.
DR   OMA; MRPAKGE; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; IEA:EnsemblFungi.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..791
FT                   /note="Ribosome biogenesis protein ERB1"
FT                   /id="PRO_0000370431"
FT   REPEAT          424..463
FT                   /note="WD 1"
FT   REPEAT          472..512
FT                   /note="WD 2"
FT   REPEAT          576..618
FT                   /note="WD 3"
FT   REPEAT          621..659
FT                   /note="WD 4"
FT   REPEAT          662..701
FT                   /note="WD 5"
FT   REPEAT          705..744
FT                   /note="WD 6"
FT   REPEAT          760..791
FT                   /note="WD 7"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          68..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          254..372
FT                   /note="Required for interaction with NOP7"
FT                   /evidence="ECO:0000250"
FT   REGION          372..408
FT                   /note="Required for interaction with YTM1"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        29..60
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   791 AA;  89794 MW;  388B06F1EA15D9F5 CRC64;
     MARKNSSLNG SESAELVVKK RVLEESELSD SEDERIEVDG LIDEEASENE AEEAEDDDSD
     AEFNRLLAEE ENGQEEEYNT SDFSEEGDAF SITDKLSNVK LTVIPETSDE GIVRTKYSDG
     RPRILKSEIN PVYDSDDSDA EAKNTIGNIP LSAYDEMPHI GYDINGKRIM RPAKGSALDQ
     LLESIELPEG WTGLLDKDSG ASLNLTEEEL ELINKLQNNQ QTDESVNPYE PLIDWFTRHE
     SVMPVTAVPE PKRRFVPSKH EAKRVMKIVK AIREGRIIPP KKLKELREKE EQDSHNYDLW
     GDAEEISEHV MNLRAPKLPP PTNEESYNPP EEYLLTPEEI DAWEKMEPSE RERNFVPHKF
     AALRKVPGYS ESVRERFERS LDLYLAPRVR KNKLNIDPES LIPELPSTKD LRPFPIRCST
     VYVGHKGKIR TMSIDPTGLW LATGSDDGTV RVWEILTGRE VYQVTILNAE ENNDDHIDVV
     EWNPDSTTGI LAVTAGENIF LLVPPIFGFE IENTGKSKIE YGFGFDTFGN VKKSNLNVNS
     DDEDDGAESH AVKKQVAQWN KPTERQAAND ICIVITCRKS VKKLSWHRKG DYFVTVQPDS
     GNTSVLIHQL SKHLTQSPFK KSKGIIMDAK FHPFKPQLLV CSQRYVRIYD LSQQVLIKKL
     LPGARWLSTI DIHPRGDNLI ASSFDKRVLW HDLDLASTPY KTLRYHEKAV RSVSFHKKLP
     LFCSAADDGN IHVFHATVYD DLMKNPMIVP LKKLTGHKIV NSLGVLDTIW HPREAWLFSA
     GADKTARLWT T