ERB1_LODEL
ID ERB1_LODEL Reviewed; 874 AA.
AC A5DWF4;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=ERB1 {ECO:0000255|HAMAP-Rule:MF_03027}; ORFNames=LELG_01690;
OS Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC Lodderomyces.
OX NCBI_TaxID=379508;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC YB-4239;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; CH981525; EDK43512.1; -; Genomic_DNA.
DR RefSeq; XP_001526862.1; XM_001526812.1.
DR AlphaFoldDB; A5DWF4; -.
DR SMR; A5DWF4; -.
DR STRING; 379508.A5DWF4; -.
DR PRIDE; A5DWF4; -.
DR EnsemblFungi; EDK43512; EDK43512; LELG_01690.
DR GeneID; 5233972; -.
DR KEGG; lel:LELG_01690; -.
DR VEuPathDB; FungiDB:LELG_01690; -.
DR eggNOG; KOG0650; Eukaryota.
DR HOGENOM; CLU_011390_0_1_1; -.
DR InParanoid; A5DWF4; -.
DR OMA; MRPAKGE; -.
DR OrthoDB; 759498at2759; -.
DR Proteomes; UP000001996; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..874
FT /note="Ribosome biogenesis protein ERB1"
FT /id="PRO_0000370432"
FT REPEAT 481..520
FT /note="WD 1"
FT REPEAT 529..569
FT /note="WD 2"
FT REPEAT 658..700
FT /note="WD 3"
FT REPEAT 703..741
FT /note="WD 4"
FT REPEAT 744..783
FT /note="WD 5"
FT REPEAT 787..827
FT /note="WD 6"
FT REPEAT 843..874
FT /note="WD 7"
FT REGION 1..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..429
FT /note="Required for interaction with NOP7"
FT /evidence="ECO:0000250"
FT REGION 429..465
FT /note="Required for interaction with YTM1"
FT /evidence="ECO:0000250"
FT REGION 593..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..79
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..94
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..111
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..144
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..620
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 874 AA; 98960 MW; E9348FA0D094F6E0 CRC64;
MAKKEVSASK PGNTKKDNVL LKKRKQQAVE KEEAEKEKEE GVSEDEFNVQ GLIDPESDSD
DEGAAAAEEE EEEEEQQQDV KELDLDKGEV ISSDSDAEDF DSEEELNKLL GEEDDPSDYS
SVGFSDEPKE DGDEQDEQDA FAAADAATDD DAFGDVKLKN LSITDPSKLE VRTKFSDGTP
RIIKPEIEPV YDSDDSDAEN FNTIGNIPIS AYEEMPHIGY DINGKRIMRP AKGSALDQLL
ESIDLPQGWT GLLDQNTGAP LKITDEELEL IRKIQQQENT DENINPYEPL NDWFTKNQEV
MPLTAVPEPK RRFVPSKHEA KRVMKIVKAI REGRILTPEK AKELKEKETE EMNYDLWQNE
SEVPDHIMNL RAPKLPPPTN EESYNPPEEY LLNEEEKQKW LEQDPVDRER NFIPQKYSSL
RLVPGYQDSV RERFERSLDL YLAPRLRKNK LNIDPESLIP ELPSPKDLRP FPIKCSTVYE
GHTGKIRTLS IDPQGLWLAT GSDDGSVRIW EVLTGRQVFK AQLVNKEHNG EDHIESLEWN
PNAQTGILAV CAGENIYLLV PPIFGFEIEN TGKLRIESGW GYDTFGNTKQ DLKVKGEDTK
GDLDDDEEEE EEEEDDDDDE GQGKVKAHNS TAPAKKDVAK WINPNSSQQA MGISAIIQCR
RTVKKISWHR KGDYFVTVSP DSKNTAVLIH QLSKHLSQSP FRKSKGVIMD AKFHPFKPQL
FVASQRQIKI YDLAQQTLLK KLLPGVRLLS TIDLHPRGDN LLAASYDKRV LWHDLDLAAT
PYKTLRYHEK AVRQIKYHKG SLPLFASASD DGIIHVFHGT VYDDLMTNPL LVPLKKLSGH
KVINQIGVLD IVWHPKEAWL FSAGADGTAR LWTT
