ERB1_MAGO7
ID ERB1_MAGO7 Reviewed; 777 AA.
AC A4R0Q1; G4MQR6;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=ERB1 {ECO:0000255|HAMAP-Rule:MF_03027}; ORFNames=MGG_09313;
OS Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS fungus) (Pyricularia oryzae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX NCBI_TaxID=242507;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX PubMed=15846337; DOI=10.1038/nature03449;
RA Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL Nature 434:980-986(2005).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; CM001231; EHA57353.1; -; Genomic_DNA.
DR RefSeq; XP_003709965.1; XM_003709917.1.
DR AlphaFoldDB; A4R0Q1; -.
DR SMR; A4R0Q1; -.
DR STRING; 318829.MGG_09313T0; -.
DR EnsemblFungi; MGG_09313T0; MGG_09313T0; MGG_09313.
DR GeneID; 2680228; -.
DR KEGG; mgr:MGG_09313; -.
DR VEuPathDB; FungiDB:MGG_09313; -.
DR eggNOG; KOG0650; Eukaryota.
DR HOGENOM; CLU_011390_0_1_1; -.
DR InParanoid; A4R0Q1; -.
DR OMA; MRPAKGE; -.
DR OrthoDB; 759498at2759; -.
DR Proteomes; UP000009058; Chromosome 1.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IEA:EnsemblFungi.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:EnsemblFungi.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..777
FT /note="Ribosome biogenesis protein ERB1"
FT /id="PRO_0000370433"
FT REPEAT 430..469
FT /note="WD 1"
FT REPEAT 473..513
FT /note="WD 2"
FT REPEAT 562..604
FT /note="WD 3"
FT REPEAT 606..645
FT /note="WD 4"
FT REPEAT 648..687
FT /note="WD 5"
FT REPEAT 691..731
FT /note="WD 6"
FT REPEAT 747..777
FT /note="WD 7"
FT REGION 1..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..71
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 87674 MW; 368CD374E87AE318 CRC64;
MAPTAPAKKR KQSAEVTELS DDEIIDGLLD GALSQSEDDS DFVASGDEDE EDEDEDEDED
KDEDDEHDDK QDIGDLQDLS LNDLDDDAQS KELAKDGANG GSGDGPEADD EDRPNYRVVE
DANGGIRYVY DEINPVYDSD DSDKEEDNRI GDIPLSFYEA YPHVGYTIDG KKLMRPSERR
QALDSLLDSI EIPKGWTGLT DPTTGKPLNL SQDELELLKR VQMNEIPEEG YDPYPDTVEY
FTGIEEKMPL SAAPEPKRRF IPSKHEAKRV MKLVRAIREG RIQPYKSKEE REKEEEGKEE
KYYDVWQDEQ PRDPHVMHIP APKLAPPGYD MSYNPPPEYL PTKAEREEWE KMDPEDREKE
YLPQKFDALR KVPGYETFVK ERFERCLDLY LAPRVRKNRL NIDPASLLPK LPRPEELKPF
PTVCQAIFRG HEGRVRSSAI DPTGLWLATG GDDGYVRIWL INPARQVWAV KLSSDEAVNA
VRWRPTKDTM ILAAAAGEEI FLMVPPDIDP EVEQTSRAVL DAGFGHAAGG ADKQTTDGKA
PAAKWARPGA RLEDEGVLVK VTVRSPVKVI SWHRRGDHFC TVSPSGQRSS VAVHTLSKHL
SQIPFRKLSG LAQVAHFHPS RPLFFVATQR TIRCYDLQRL ELVKVVQPGA RWISSFDIHP
GGDNLIVGSY DRRLLWHDLD LSTRPYKTMR FHPQAIRAVK YHRGGLPLFA DASDDGSLQI
FHGKVVSDLM ENATIVPLKS LKGHRVVDSL GVMDVDWHPS EPWCISAGAD GTCRLWM
