ERB1_NEOFI
ID ERB1_NEOFI Reviewed; 790 AA.
AC A1D3F5;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Ribosome biogenesis protein erb1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=erb1; ORFNames=NFIA_016440;
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC / WB 181;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of erb1, nop7 and
CC ytm1. The complex is held together by erb1, which interacts with nop7
CC via its N-terminal domain and with ytm1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; DS027688; EAW22948.1; -; Genomic_DNA.
DR RefSeq; XP_001264845.1; XM_001264844.1.
DR AlphaFoldDB; A1D3F5; -.
DR SMR; A1D3F5; -.
DR STRING; 36630.CADNFIAP00000659; -.
DR EnsemblFungi; EAW22948; EAW22948; NFIA_016440.
DR GeneID; 4591388; -.
DR KEGG; nfi:NFIA_016440; -.
DR VEuPathDB; FungiDB:NFIA_016440; -.
DR eggNOG; KOG0650; Eukaryota.
DR HOGENOM; CLU_011390_0_1_1; -.
DR OMA; MRPAKGE; -.
DR OrthoDB; 759498at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IEA:EnsemblFungi.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:EnsemblFungi.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..790
FT /note="Ribosome biogenesis protein erb1"
FT /id="PRO_0000370435"
FT REPEAT 428..467
FT /note="WD 1"
FT REPEAT 471..511
FT /note="WD 2"
FT REPEAT 613..651
FT /note="WD 3"
FT REPEAT 654..699
FT /note="WD 4"
FT REPEAT 703..744
FT /note="WD 5"
FT REPEAT 760..790
FT /note="WD 6"
FT REGION 1..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..80
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 790 AA; 87986 MW; FBC2BB3CA7369891 CRC64;
MNGSKASKKR KAVTRDVEEE AGVFSGDELN TDNLDGALSD NANDLSSDED ESDSEVELID
DFSDEDDEEE EDVLDSDEIP SDGEDLAKKK SNTAPGELGA AMDDGESSSE GEQLNYRIEK
DANGNDRFVY DEINPDDNSE YSDIEENANT IGDIPLSFYD QYPHIGYDIN GKKILRPAKG
EALDALLDSI EIPKGWTGLT DPSTGKPLEL SQEELELLRK VQMNEIPEDG YNPYEPTVEW
FTSQQEIMPL SAAPEPKRRF VPSKHEAKRV MKIVKAIREG RILPFKPPTE EDEEDDTIIK
YDLWADEAER KDHPMHIPAP KLPPPGYEES YHPPPEYLPS QKERKAWEEA DPEDRASEFL
PNDFGSLRRV PGYENFVKEK FERCLDLYLA PRVRRSKLNI DPESLLPKLP SPEELKPFPT
ACATVFRGHK GRVRTLAVDP SGLLLATGGD DGTVRVWELL TGRQLWSVKL SEEDPVNVVR
WRPGKDALIL AAAAGDDIFL AVPPIVDPAI EKASLDILDA GWGYAASVPP PTPAEANKKN
NPPKWMRPSS SLADLGVCAV IPLRYVAKSL SWHRRGDYFV TVCPGSSTPA SVAIAIHTLS
KHLTQYPFRR RIKGGGPPQA AHFHPSKPIL FVANQRSIRA YDLSRQLLVK ILQPGARWIS
SFDIHPTSST ASGGDNLIVG SYDRRLLWHD LELSQRPYKT LRYHRKAIRA VKFHPGGRYP
LFADASDDGS LQIFHGSVTG DMLSNATIVP LKVLKGHKIT GELGVLDVDW HPREPWCVSA
GADGTCRLWM
