ID   ERB1_NEUCR              Reviewed;         779 AA.
AC   Q7SEM3;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Ribosome biogenesis protein erb1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE   AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN   Name=erb1; ORFNames=NCU03321;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Component of the NOP7 complex, which is required for
CC       maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBUNIT: Component of the NOP7 complex, composed of erb1, nop7 and
CC       ytm1. The complex is held together by erb1, which interacts with nop7
CC       via its N-terminal domain and with ytm1 via a high-affinity interaction
CC       between the seven-bladed beta-propeller domains of the 2 proteins. The
CC       NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC       Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR   EMBL; CM002236; EAA35262.1; -; Genomic_DNA.
DR   RefSeq; XP_964498.1; XM_959405.2.
DR   AlphaFoldDB; Q7SEM3; -.
DR   SMR; Q7SEM3; -.
DR   STRING; 5141.EFNCRP00000002818; -.
DR   EnsemblFungi; EAA35262; EAA35262; NCU03321.
DR   GeneID; 3880647; -.
DR   KEGG; ncr:NCU03321; -.
DR   VEuPathDB; FungiDB:NCU03321; -.
DR   HOGENOM; CLU_011390_0_1_1; -.
DR   InParanoid; Q7SEM3; -.
DR   OMA; MRPAKGE; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; IBA:GO_Central.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IBA:GO_Central.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..779
FT                   /note="Ribosome biogenesis protein erb1"
FT                   /id="PRO_0000370436"
FT   REPEAT          430..469
FT                   /note="WD 1"
FT   REPEAT          473..513
FT                   /note="WD 2"
FT   REPEAT          564..606
FT                   /note="WD 3"
FT   REPEAT          609..647
FT                   /note="WD 4"
FT   REPEAT          650..689
FT                   /note="WD 5"
FT   REPEAT          693..733
FT                   /note="WD 6"
FT   REPEAT          749..779
FT                   /note="WD 7"
FT   REGION          1..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..72
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..89
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        100..124
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   779 AA;  87713 MW;  C90F2CA837BD4228 CRC64;
     MGPKATEKKR KVQDAEPESD DEIAPDFDGA LSQSEDEFDS DFDDNEHEQD GEQESGSEAS
     DDEDEEGSLL SDDIPSDAEG DKAMGKLVLE DEEEELEIEI PGVDPKRPEK DDGDKNYRIE
     KDANGNERYV YDEIDPVYDS DDSDAQEAPN TIGNIPMSFY DSYPHIGYDI NGKKIMRPAT
     GDALDALLDS IEVPKGWTGL TDIHTGNPLN LNDDELELVR RVQMGMIPNE LENPYPETVE
     YFTGIEEKMP LSAAPEPKRR FLPSKNEAKK IMKLVRAIRE GRILPYKPPE EREKEEEEEE
     QYFDIWQDEV PQEVNPLHIP APKLPPPGFD MSYNPPAEYL PTKEEREEWE KLDPEEREKE
     YLPQKYDSLR KVPGYGEIVK ERFERCMDLY LAPRVRKNRL NIDPNSLLPK LPSPSELKPF
     PTVAQTVFRG HDGRVRSVAI DPTGVAVASG GDDGTVRVWE LLTGRQVWSV KLSSEEAVNT
     VRWRPAKDSF ILSAAVGEDV YLMVPTHASV TPALDQASRD ILSAGFGYAT NGQQHGAAPG
     KEPPAKWARP GAKLEDEGVL IRITVRSTVK VINWHRKGDH FATVSPSGQR SSVAIHTLSK
     HLTQIPFRKL SGLAQTASFH PLRPLFFVAT QRTIRCYDLQ KLELVKVVQP GAKWISSFDI
     HPGGDNLIVG SYDKRLLWHD LDLSIRPYKT MRFHSEAVRQ VKYHRGGLPL FADASDDGTL
     QIFHGKVPND QLENPTIVPV KVLKGHKVVN KLGVLDMDWH PREPWCVSAG ADGTIRLWM