ERB1_PICGU
ID ERB1_PICGU Reviewed; 790 AA.
AC A5DBG1;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=ERB1 {ECO:0000255|HAMAP-Rule:MF_03027}; ORFNames=PGUG_00616;
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; CH408155; EDK36518.2; -; Genomic_DNA.
DR RefSeq; XP_001487239.1; XM_001487189.1.
DR AlphaFoldDB; A5DBG1; -.
DR SMR; A5DBG1; -.
DR STRING; 4929.XP_001487239.1; -.
DR PRIDE; A5DBG1; -.
DR EnsemblFungi; EDK36518; EDK36518; PGUG_00616.
DR GeneID; 5128820; -.
DR KEGG; pgu:PGUG_00616; -.
DR VEuPathDB; FungiDB:PGUG_00616; -.
DR eggNOG; KOG0650; Eukaryota.
DR HOGENOM; CLU_011390_0_1_1; -.
DR InParanoid; A5DBG1; -.
DR OMA; MRPAKGE; -.
DR OrthoDB; 759498at2759; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..790
FT /note="Ribosome biogenesis protein ERB1"
FT /id="PRO_0000370438"
FT REPEAT 423..462
FT /note="WD 1"
FT REPEAT 470..510
FT /note="WD 2"
FT REPEAT 574..616
FT /note="WD 3"
FT REPEAT 619..657
FT /note="WD 4"
FT REPEAT 660..699
FT /note="WD 5"
FT REPEAT 703..743
FT /note="WD 6"
FT REPEAT 759..790
FT /note="WD 7"
FT REGION 1..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..371
FT /note="Required for interaction with NOP7"
FT /evidence="ECO:0000250"
FT REGION 371..407
FT /note="Required for interaction with YTM1"
FT /evidence="ECO:0000250"
FT COMPBIAS 23..89
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 790 AA; 89709 MW; 363A7394F12DC2EE CRC64;
MAKKNTVTGS KIKRKRQDES PEVSESEEID VQGLIDDEAS EDSEDEVESE DQVFENSDAD
SDEELNNLIG EEEDVSDVDS EDFSDELQDD SNSITDKLTN VRIRTSSQSS NENVHGLFAD
GTERIIKPEI EPVYDSDDSD HENFNTIGNI PLSAYEEMPH IGYDINGKRI MRPAKGSALD
QLLESIDLPE GWTGLLDQNT GSSLKLTDEE LELIRKIQHN ENTDDNINPY EPTIEWFTSK
TEVMPLTAVP EPKRRFVPSK HEAKRIMKIV RAIRDGRIVP PEKRKEQQDE EQYNFDLWDD
NTDEPNEHIM NLRAPKLPPP TNEESYNPPE EYLMTEEERK KWEETDPSER ETNFIPQKYG
SLRKVPAYQE NLRERFERSL DLYLAPRVRH NKLNIDPDSL IPDLPSPKDL RPFPIKCSTI
FQGHIGRVRT LSIDPSGLWL ATGGDDGTVR VWEILTGRQV YHCDVVDKKK DDDNIDSLEW
NPDASVGILA VAAGESVYLL VPTILGYEIE NAGRSKIEVG WGYDTYGNKN KRGDLNVNGE
EDNESGANEV KKEVTKWLTP MEGQSQQGIA AIIQCRKAVK NLSWHRKGDY FVTVSPDSGN
TSVLIHQLSK HLSQSPFRKS KGIIVDAKFH PFKPQLFVAS QRSIKIYDLS QQVLTKKLMP
GARYLSGIDI HPRGDHLLAS SYDKRVLWHD LDLSNTPYKT LRYHEKAVRN IKFHKGRLPL
FASASDDGSV HVFHGTVYDD LMTNPLLVPL KKLTGHKVVH SLGVLDLVWH PKEAWLFTAG
ADGTARLWTT
