ERB1_PODAN
ID ERB1_PODAN Reviewed; 784 AA.
AC B2AY28; A0A090C998;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=ERB1 {ECO:0000255|HAMAP-Rule:MF_03027}; OrderedLocusNames=Pa_1_9660;
GN ORFNames=PODANS_1_9660;
OS Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)
OS (Pleurage anserina).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Podosporaceae; Podospora;
OC Podospora anserina.
OX NCBI_TaxID=515849;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S / ATCC MYA-4624 / DSM 980 / FGSC 10383;
RX PubMed=18460219; DOI=10.1186/gb-2008-9-5-r77;
RA Espagne E., Lespinet O., Malagnac F., Da Silva C., Jaillon O., Porcel B.M.,
RA Couloux A., Aury J.-M., Segurens B., Poulain J., Anthouard V.,
RA Grossetete S., Khalili H., Coppin E., Dequard-Chablat M., Picard M.,
RA Contamine V., Arnaise S., Bourdais A., Berteaux-Lecellier V., Gautheret D.,
RA de Vries R.P., Battaglia E., Coutinho P.M., Danchin E.G.J., Henrissat B.,
RA El Khoury R., Sainsard-Chanet A., Boivin A., Pinan-Lucarre B., Sellem C.H.,
RA Debuchy R., Wincker P., Weissenbach J., Silar P.;
RT "The genome sequence of the model ascomycete fungus Podospora anserina.";
RL Genome Biol. 9:R77.1-R77.22(2008).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=S / ATCC MYA-4624 / DSM 980 / FGSC 10383;
RX PubMed=24558260; DOI=10.1534/genetics.113.159988;
RA Grognet P., Bidard F., Kuchly C., Tong L.C.H., Coppin E., Benkhali J.A.,
RA Couloux A., Wincker P., Debuchy R., Silar P.;
RT "Maintaining two mating types: Structure of the mating type locus and its
RT role in heterokaryosis in Podospora anserina.";
RL Genetics 197:421-432(2014).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; CU633901; CAP69302.1; -; Genomic_DNA.
DR EMBL; FO904936; CDP23321.1; -; Genomic_DNA.
DR RefSeq; XP_001908629.1; XM_001908594.1.
DR AlphaFoldDB; B2AY28; -.
DR SMR; B2AY28; -.
DR STRING; 5145.XP_001908629.1; -.
DR PRIDE; B2AY28; -.
DR EnsemblFungi; CAP69302; CAP69302; PODANS_1_9660.
DR GeneID; 6193097; -.
DR KEGG; pan:PODANSg5664; -.
DR VEuPathDB; FungiDB:PODANS_1_9660; -.
DR eggNOG; KOG0650; Eukaryota.
DR HOGENOM; CLU_011390_0_1_1; -.
DR OrthoDB; 759498at2759; -.
DR Proteomes; UP000001197; Chromosome 1.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..784
FT /note="Ribosome biogenesis protein ERB1"
FT /id="PRO_0000370440"
FT REPEAT 435..474
FT /note="WD 1"
FT REPEAT 478..520
FT /note="WD 2"
FT REPEAT 569..611
FT /note="WD 3"
FT REPEAT 655..693
FT /note="WD 4"
FT REPEAT 698..738
FT /note="WD 5"
FT REPEAT 754..784
FT /note="WD 6"
FT REGION 1..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..84
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 784 AA; 88147 MW; DF891245E2833FAB CRC64;
MKSKPVEKKR KVRDEESDSE SDDELANGLF DGVLEASEDE EDYIPSDEID DVDSESEVSE
GSEDAEEEEE EEEGDDDALL SDDIPSDDEM GKLSKDAEEL EITEPGVDPK PKHQEEEDRN
YKVVKDANGG ERYVYDEIDP VYDSDDSDAQ GPVNTIGNIP LSFYDSYPHI GYDINGKKIM
RPATGDALQS LLDTIEVPKG WTGLTDVNTG NPLNLTQEEL ELVRRVQHGL VPDEGYDPYP
DTVEWFTSKQ ETMPLSAAPE PKRRFLPSKN EAKQVMKLVR AIREGRILPY KPPEEREREE
EEKEEVQFDI WQDEEPAAPN PMHIPAPKLP PPGYEMSYNP PEEYLPTEEE REEWEKTDPE
DREKEFLPQK FNSLRKVPAW GTLVKERFER CMDLYLAPRV RKNRLNIDPN SLLPKLPSPA
ELKPFPTVVQ TIFRGHEGTV RSIAIDPTGV ALATGGSDGT VRVWELLTGR QVWSVKLSSE
DPVYTVRWRP TKDAFVLAAS AGEDVFLMVP PHSSVTPTLD QASRDVLAAG FGYATNGQQP
ATAPGKEPAG KWARPGTKLE DAGVLVRVTV RSAVKVITWH RRGDHFATVS PEGQRSSVAI
HTLSKHLTQI PFRKLHGLAQ TVVFHPLKPL FFVATMRTVR CYDLQKVELV KIVQPGAKWI
SSLDIHSGGD HLIVGSYDRR LLWHDLDLSN RPHKTMRFHP KAIRAVRFHK GGLPLFADAS
DDGTLQIFYG KVPNDQLESP TIVPVKQLKG HKVVNQVGVV DIDWHPREPW CVSAGADGTA
RLWM
