ERB1_PYRTR
ID ERB1_PYRTR Reviewed; 781 AA.
AC B2VR76;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Ribosome biogenesis protein erb1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=erb1; ORFNames=PTRG_00503;
OS Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus)
OS (Drechslera tritici-repentis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae;
OC Pyrenophora.
OX NCBI_TaxID=426418;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pt-1C-BFP;
RX PubMed=23316438; DOI=10.1534/g3.112.004044;
RA Manning V.A., Pandelova I., Dhillon B., Wilhelm L.J., Goodwin S.B.,
RA Berlin A.M., Figueroa M., Freitag M., Hane J.K., Henrissat B., Holman W.H.,
RA Kodira C.D., Martin J., Oliver R.P., Robbertse B., Schackwitz W.,
RA Schwartz D.C., Spatafora J.W., Turgeon B.G., Yandava C., Young S., Zhou S.,
RA Zeng Q., Grigoriev I.V., Ma L.-J., Ciuffetti L.M.;
RT "Comparative genomics of a plant-pathogenic fungus, Pyrenophora tritici-
RT repentis, reveals transduplication and the impact of repeat elements on
RT pathogenicity and population divergence.";
RL G3 (Bethesda) 3:41-63(2013).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of erb1, nop7 and
CC ytm1. The complex is held together by erb1, which interacts with nop7
CC via its N-terminal domain and with ytm1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; DS231615; EDU39941.1; -; Genomic_DNA.
DR RefSeq; XP_001930836.1; XM_001930801.1.
DR AlphaFoldDB; B2VR76; -.
DR SMR; B2VR76; -.
DR STRING; 45151.EDU39941; -.
DR EnsemblFungi; EDU39941; EDU39941; PTRG_00503.
DR GeneID; 6338364; -.
DR eggNOG; KOG0650; Eukaryota.
DR HOGENOM; CLU_011390_0_1_1; -.
DR InParanoid; B2VR76; -.
DR OMA; MRPAKGE; -.
DR OrthoDB; 759498at2759; -.
DR Proteomes; UP000001471; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IEA:EnsemblFungi.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:EnsemblFungi.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..781
FT /note="Ribosome biogenesis protein erb1"
FT /id="PRO_0000370441"
FT REPEAT 431..470
FT /note="WD 1"
FT REPEAT 474..515
FT /note="WD 2"
FT REPEAT 611..651
FT /note="WD 3"
FT REPEAT 652..691
FT /note="WD 4"
FT REPEAT 695..735
FT /note="WD 5"
FT REPEAT 751..781
FT /note="WD 6"
FT REGION 1..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..73
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 781 AA; 87870 MW; ED0F753FFF07C8DC CRC64;
MSVNPRKRKV VTRPAPEPSD SEGELGDGLL EGILSHSEDD SDNSREEEVD TDASSVIEGL
SDEDEEEDED SDSEQIRTEM RNLNTSDGPL RKKKGVPTHD MDLDTAVTEE LEDDEDLKPN
YTVTTDAHGN TRYIYKEIDP VYESDDSDVE ATNTIGNIDL KYYDEYPHIG YDINGKKIMR
PAKGEALDAL LDSIDIPKGW TGLTDPQTGK PLNLSEEELD VLKRLTRNEV VEDGYDPYPE
MVAYFSGKQE IMPLSAAPEP KRRFIPSKHE AKRVMKLVKA IREGRIQPYR APEEQEEEQD
AFNFDVWADE KPRPDNSMHI PAPKLPPPGY EASYHPPPEY LPDKAEEQAW LEADEEDRER
EFLPKNYDAL RKVPGYETFV KERFERSLDL YLAPRIRRNR LNIDPESLLP KLPNPEDLKP
FPTTCAAIFR GQEGRVRCVS IDPNGIFVAS GGDDGYVRIW ELLTGRQVWN AKLSDEEAVD
AVQWRPKKDA SVVAAACGEN VFLIVPFTLL SPDVEQASRE VLDAGWGYAT SKPSTSSNGE
APKQAPGKWS RPGARLENKG VLVQVEVRSA VKIVNWHRRG DYFATVSPRG QSTAVAIHTV
SKHLTQLPFR RLKGIAQTAQ FHPSKAIFFV ATRNTIRSYD LAKQELVKIL QPGAKWISSI
DVHPGGDNLI VGTYDKRLLW HDLDLSNKPY KTLRFHKEAI RAVRFHQGGL PLFADTSDDG
TIQIFHGKVV GDLMENATIV PLKVLKGHKV RSRLGVMGLD WHPKEPWCVS AGADGTLRLW
S
