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ERB1_USTMA
ID   ERB1_USTMA              Reviewed;         932 AA.
AC   Q4P2E9; A0A0D1DSR7;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE   AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN   Name=ERB1 {ECO:0000255|HAMAP-Rule:MF_03027}; ORFNames=UMAG_05714;
OS   Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=237631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=521 / FGSC 9021;
RX   PubMed=17080091; DOI=10.1038/nature05248;
RA   Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA   Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA   Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA   Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA   Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA   Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA   Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA   Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA   Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA   Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA   Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA   Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA   Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA   Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA   Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA   Birren B.W.;
RT   "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT   maydis.";
RL   Nature 444:97-101(2006).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=521 / FGSC 9021;
RA   Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the NOP7 complex, which is required for
CC       maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC       YTM1. The complex is held together by ERB1, which interacts with NOP7
CC       via its N-terminal domain and with YTM1 via a high-affinity interaction
CC       between the seven-bladed beta-propeller domains of the 2 proteins. The
CC       NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC       Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR   EMBL; CM003155; KIS66931.1; -; Genomic_DNA.
DR   RefSeq; XP_011391464.1; XM_011393162.1.
DR   AlphaFoldDB; Q4P2E9; -.
DR   SMR; Q4P2E9; -.
DR   STRING; 5270.UM05714P0; -.
DR   EnsemblFungi; KIS66931; KIS66931; UMAG_05714.
DR   GeneID; 23565526; -.
DR   KEGG; uma:UMAG_05714; -.
DR   VEuPathDB; FungiDB:UMAG_05714; -.
DR   eggNOG; KOG0650; Eukaryota.
DR   HOGENOM; CLU_011390_0_1_1; -.
DR   InParanoid; Q4P2E9; -.
DR   OMA; MRPAKGE; -.
DR   OrthoDB; 759498at2759; -.
DR   Proteomes; UP000000561; Chromosome 16.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; IBA:GO_Central.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IBA:GO_Central.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..932
FT                   /note="Ribosome biogenesis protein ERB1"
FT                   /id="PRO_0000370442"
FT   REPEAT          555..594
FT                   /note="WD 1"
FT   REPEAT          604..644
FT                   /note="WD 2"
FT   REPEAT          762..800
FT                   /note="WD 3"
FT   REPEAT          803..842
FT                   /note="WD 4"
FT   REPEAT          846..885
FT                   /note="WD 5"
FT   REPEAT          901..932
FT                   /note="WD 6"
FT   REGION          1..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          679..698
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..38
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..115
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..167
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..194
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..220
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   932 AA;  103046 MW;  B9FEF03EF3673F02 CRC64;
     MVRPSSSSSA SASAARSGAA KRKRNLPTAT NPTTRASVAA NVKGKGKTKA LELDLVVSDD
     GEEDGELDLE SDSGDDDAND DDDNDNEQDD FPEIDLEDSD DDQDVEDEDE PGAQEEVDSD
     NNKQASTQVH DIQVEEDDSS EEGYNSSDID NSDFDDDADE GDLAYDSADE DERASAFAAR
     SDASQTSIDE ELSRMMSRYS SKPDEHSGSL SATNKLGIPR SQAAQAFDLR VRNPDGSAKG
     VFKRSEITGE MKRVYPEIDA AYDSDSSTED PENRIGNVPL EWYDDLPHIG YDINGRKVMK
     PATKDELDKF LDTVDGDGEA WFSARDKSTG KDVRLSDEEL AIIRKLQNAE IPDDAYDPYE
     DYVDWFTGED KVMQTALSGR PEPKSRFVPS KWEHKKVMKI VRAIREGRIV PGAAANKDAK
     PKFYNIWADA HENDTRSPWA VMAAPKLALP GHAESYNPPA EYLFNEQEQK EWQEAEAEDR
     KQNFLPTKHD SLRRVGAYQN FVQERFERCL DLYLAPRMMR KKLDIHNPEN LLPKLPSPKE
     LRPFPITTSV VYVHPDGGRV RCLSVDPTGN WLVTGGDDGR ARLWDVAIGR CTASWDVCEG
     MPKAERSAVH SIAWCPTKNY SLFTAVVHGR VAVIAPPQTQ NYAKTSANAI SSKSASSSSG
     ATATSTASFL YATSAAATSM PSKPDARSPV AWTRPSEAER RTGVAMHLNI TSPSAANLKT
     VVWHNKGDYF ATVCPDSAAG SAGLLIHQLS KHRSQSPFRK ASKGSSIQKL VFHPTKPWIF
     VATQRYIRIY DLMAQSLIKT LQSGFKWIST LDVHPSGDHL MVGSYDKKLA WFDLDLSARP
     YKVLKYHARA IRSVHFSTSW NLVADASDDG TLQLFYAKVG ADYGENLTLV PLKVLRGHEV
     KNGLGVLDVK WHPNQPWLFS AGADGNALLW TT
 
 
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