ERB1_YARLI
ID ERB1_YARLI Reviewed; 820 AA.
AC Q6C4I9;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN OrderedLocusNames=YALI0E26389g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; CR382131; CAG80024.1; -; Genomic_DNA.
DR RefSeq; XP_504423.1; XM_504423.1.
DR AlphaFoldDB; Q6C4I9; -.
DR SMR; Q6C4I9; -.
DR STRING; 4952.CAG80024; -.
DR PRIDE; Q6C4I9; -.
DR EnsemblFungi; CAG80024; CAG80024; YALI0_E26389g.
DR GeneID; 2912374; -.
DR KEGG; yli:YALI0E26389g; -.
DR VEuPathDB; FungiDB:YALI0_E26389g; -.
DR HOGENOM; CLU_011390_0_1_1; -.
DR InParanoid; Q6C4I9; -.
DR OMA; MRPAKGE; -.
DR Proteomes; UP000001300; Chromosome E.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IBA:GO_Central.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IBA:GO_Central.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR17605; PTHR17605; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..820
FT /note="Ribosome biogenesis protein ERB1"
FT /id="PRO_0000370443"
FT REPEAT 447..486
FT /note="WD 1"
FT REPEAT 495..535
FT /note="WD 2"
FT REPEAT 604..646
FT /note="WD 3"
FT REPEAT 649..687
FT /note="WD 4"
FT REPEAT 690..729
FT /note="WD 5"
FT REPEAT 733..773
FT /note="WD 6"
FT REPEAT 789..820
FT /note="WD 7"
FT REGION 1..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..395
FT /note="Required for interaction with NOP7"
FT /evidence="ECO:0000250"
FT REGION 395..431
FT /note="Required for interaction with YTM1"
FT /evidence="ECO:0000250"
FT REGION 545..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..47
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..104
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 820 AA; 91965 MW; 1F9E7965859E7013 CRC64;
MVRSRSNSVK KDLKRKVDEP VDVQDEFDVE GLIDEGDSDD EDEAEQEVAQ ENVTKDKKNT
SKTENEEDAD DESDSDAELE ALIGEEEDLS GSELEDELAY FSDAGDDEVD PSILKHLDDG
VRLRSLSRSS DQTDELKDVV EIVPGADGKP RMIKKEIHAV YDSDDSDQEE SNTIGNVPLS
AYDQMPHIGY DINGKRIMRP ATGSALDNLL ETIDLPEGWT GLLDKSTGKG LNISKEELEL
IKRIQKNETT DDASNPYEDL VEWFSSKTEI MPLSAAPEPK RRFIPSKHEA KRVMKMVQAI
RQGKLLTKPK EDPDARPNYD VWADNLTDVQ DHVMTLRAPK MPPPTHDESY NPPAEYLPTE
EEIAEWNALA PSERERNYVP KKYTALRHVP GYSESVRERF ERSLDLYLAP RVRKNKLNID
PDSLIPDLPS PKDLMPFPIR CATTYKGHKG KVRAISVDPS GEFLATGGDD GTLRVWEVLT
GRELYRCRLV ASIDAQDDSV ECVQWNPAVP GMLAASAGEH IFLIVPPTLF DFDIENTGRE
KIEQGWGFAE GGREQQDIDT KGLDDDADSD SDDETGHVKK KSPPAKWITP TAKQQASGIG
AIITATKTIK RLAWHRKGDY LVTVAPSAQH RAVAIHQISK HSSQSPFNKS KGIVQDAMFH
PFRPHLYVAT QRYVRIYDLA KQVMAKKLMP GARWVSSLDI HPRGDNVILS SFDKRLLWHD
LDLSDKPYKT LRYHEKAVRH AAFHKGGLPL FCSASDDGNI NIFHGTVYDD MMTNPLLVPL
KVLKGHDVKS GLGILRVEWH PREAWLFSAA ADGTAKLWTT
