ID   ERBS_SACEN              Reviewed;         366 AA.
AC   P14290; A4F7Q1;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   22-FEB-2012, sequence version 2.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Erythromycin biosynthesis sensory transduction protein EryC1;
GN   Name=eryC1; Synonyms=eryCI; OrderedLocusNames=SACE_0734;
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS   NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL
RC   2338;
RX   PubMed=2575703; DOI=10.1111/j.1365-2958.1989.tb00123.x;
RA   Dhillon N., Hale R.S., Cortes J., Leadlay P.F.;
RT   "Molecular characterization of a gene from Saccharopolyspora erythraea
RT   (Streptomyces erythraeus) which is involved in erythromycin biosynthesis.";
RL   Mol. Microbiol. 3:1405-1414(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL
RC   2338;
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA   Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
CC   -!- FUNCTION: Sensor protein that transfers the signal of environmental
CC       stimuli to the regulatory region of target genes to activate or repress
CC       transcription of erythromycin biosynthesis genes. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Peripheral membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DegT/DnrJ/EryC1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X15541; CAA33548.1; -; Genomic_DNA.
DR   EMBL; AM420293; CAM00075.1; -; Genomic_DNA.
DR   PIR; S06725; S06725.
DR   RefSeq; WP_009950389.1; NZ_PDBV01000001.1.
DR   AlphaFoldDB; P14290; -.
DR   SMR; P14290; -.
DR   STRING; 405948.SACE_0734; -.
DR   EnsemblBacteria; CAM00075; CAM00075; SACE_0734.
DR   KEGG; sen:SACE_0734; -.
DR   eggNOG; COG0399; Bacteria.
DR   HOGENOM; CLU_033332_6_0_11; -.
DR   OMA; IGCEIYY; -.
DR   OrthoDB; 1006364at2; -.
DR   BioCyc; MetaCyc:MON-17089; -.
DR   Proteomes; UP000006728; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   CDD; cd00616; AHBA_syn; 1.
DR   Gene3D; 3.40.640.10; -; 1.
DR   Gene3D; 3.90.1150.10; -; 1.
DR   InterPro; IPR000653; DegT/StrS_aminotransferase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR30244; PTHR30244; 1.
DR   Pfam; PF01041; DegT_DnrJ_EryC1; 1.
DR   PIRSF; PIRSF000390; PLP_StrS; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis; Cell membrane; DNA-binding; Membrane;
KW   Pyridoxal phosphate; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..366
FT                   /note="Erythromycin biosynthesis sensory transduction
FT                   protein EryC1"
FT                   /id="PRO_0000110012"
FT   DNA_BIND        160..179
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
FT   REGION          53..158
FT                   /note="Hydrophobic"
FT   MOD_RES         186
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        69
FT                   /note="L -> V (in Ref. 1; CAA33548)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        92..95
FT                   /note="AVSR -> GVP (in Ref. 1; CAA33548)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   366 AA;  39410 MW;  DAC755AB6890F279 CRC64;
     MDVPFLDLQA AYLELRSDID QACRRVLGSG WYLHGPENEA FEAEFAAYCE NAHCVTVGSG
     CDALELSLLA LGVGQGDEVI VPSHTFIATW LAVSRVGAVP VPVEPEGVSH TLDPALVEQA
     ITPRTAAILP VHLYGHPADL DALRAIADRH GLALVEDVAQ AVGARHRGHR VGAGSNAAAF
     SFYPGKNLGA LGDGGAVVTT DPALAERIRL LRNYGSKQKY VHEVRGTNAR LDELQAAVLR
     VKLRHLDDWN ARRTTLAQHY QTELKDVPGI TLPETHPWAD SAWHLFVLRC ENRDHLQRHL
     TDAGVQTLIH YPTPVHLSPA YADLGLPPGS FPVAESLAGE VLSLPIGPHL SREAADHVIA
     TLKAGA