ID   ERCC1_DICDI             Reviewed;         514 AA.
AC   Q55GG6;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=DNA excision repair protein ERCC-1;
GN   Name=ercc1; ORFNames=DDB_G0267682;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Structure-specific DNA repair endonuclease responsible for
CC       the 5'-incision during DNA repair. {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer composed of ercc1 and xpf/errc4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ERCC1/RAD10/SWI10 family. {ECO:0000305}.
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DR   EMBL; AAFI02000003; EAL73294.1; -; Genomic_DNA.
DR   RefSeq; XP_647218.1; XM_642126.1.
DR   AlphaFoldDB; Q55GG6; -.
DR   SMR; Q55GG6; -.
DR   STRING; 44689.DDB0232362; -.
DR   PaxDb; Q55GG6; -.
DR   EnsemblProtists; EAL73294; EAL73294; DDB_G0267682.
DR   GeneID; 8616022; -.
DR   KEGG; ddi:DDB_G0267682; -.
DR   dictyBase; DDB_G0267682; ercc1.
DR   eggNOG; KOG2841; Eukaryota.
DR   HOGENOM; CLU_530448_0_0_1; -.
DR   InParanoid; Q55GG6; -.
DR   OMA; NTEMENQ; -.
DR   Reactome; R-DDI-5696395; Formation of Incision Complex in GG-NER.
DR   Reactome; R-DDI-6782135; Dual incision in TC-NER.
DR   PRO; PR:Q55GG6; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0070522; C:ERCC4-ERCC1 complex; IBA:GO_Central.
DR   GO; GO:0000110; C:nucleotide-excision repair factor 1 complex; ISS:dictyBase.
DR   GO; GO:0003684; F:damaged DNA binding; IBA:GO_Central.
DR   GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0000014; F:single-stranded DNA endodeoxyribonuclease activity; ISS:dictyBase.
DR   GO; GO:0000710; P:meiotic mismatch repair; IBA:GO_Central.
DR   GO; GO:0006312; P:mitotic recombination; IBA:GO_Central.
DR   GO; GO:0006289; P:nucleotide-excision repair; ISS:dictyBase.
DR   GO; GO:0006296; P:nucleotide-excision repair, DNA incision, 5'-to lesion; IBA:GO_Central.
DR   GO; GO:0070914; P:UV-damage excision repair; IBA:GO_Central.
DR   InterPro; IPR004579; ERCC1/RAD10/SWI10.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR010994; RuvA_2-like.
DR   PANTHER; PTHR12749; PTHR12749; 1.
DR   Pfam; PF03834; Rad10; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF52980; SSF52980; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; DNA-binding; Endonuclease; Hydrolase; Nuclease;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..514
FT                   /note="DNA excision repair protein ERCC-1"
FT                   /id="PRO_0000331367"
FT   REGION          1..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          426..514
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        426..483
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   514 AA;  56615 MW;  D826A691D50C7FFC CRC64;
     MSSQQTDNNP IPTTTTNNNT NNDNDIASTN NNTNNDDDST TTNTSTNKPR KRFVIPSASQ
     ALKKSDLSMV EINSKLKQAE ENAKQAEDLQ KSNAIILTPK STTTMTTTTT PVQQRMPIPS
     ILAKRNVNTT TTTSTSPLST SPPISSPLQT PYYSPSFVKN PTSPAPINKP IGPSLPMRPS
     LPKKPAAYST TLSTYSSSSS SYSSSTTTQN YQHIDKIYAN SKQRGSLMMN SFSKNIIIEY
     SELQYPDFIL NSNTLVFYLP SLKTHRDNPN LIQDRIKGLS TLMTNSDSFT LRILLVFADL
     SDSDNCEQFI NELNLIAIKL QFTLIVCWSQ IEAAKYLEAY KTFNNRAPDP IKARAQPIEL
     GGKSKNEQVL TSIKSVNKTD ATTLLKNFQT MQQIFTCQKT TLSKLPGFGP VKVQKFYNTI
     NQPFKTKPST KTTTTTTTTT TTTTSANISS NNNNNNINTN DGNNNNNTIN NINFNNDENE
     VDQDPLNFSF DFGGNGNGDG DSDGDGESEN QINT