AGP3_YEAST
ID AGP3_YEAST Reviewed; 558 AA.
AC P43548; D6VTH5;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=General amino acid permease AGP3;
GN Name=AGP3; OrderedLocusNames=YFL055W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7670463; DOI=10.1038/ng0795-261;
RA Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S.,
RA Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H.,
RA Eki T.;
RT "Analysis of the nucleotide sequence of chromosome VI from Saccharomyces
RT cerevisiae.";
RL Nat. Genet. 10:261-268(1995).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP CHARACTERIZATION.
RA Garrett J.M., Schreve J.L.;
RL Unpublished observations (JUL-1997).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- FUNCTION: General amino acid permease with broad substrate specificity.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. YAT (TC 2.A.3.10) family. {ECO:0000305}.
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DR EMBL; D50617; BAA09186.1; -; Genomic_DNA.
DR EMBL; BK006940; DAA12385.1; -; Genomic_DNA.
DR PIR; S56200; S56200.
DR RefSeq; NP_116600.1; NM_001179912.1.
DR AlphaFoldDB; P43548; -.
DR SMR; P43548; -.
DR BioGRID; 31092; 52.
DR DIP; DIP-4160N; -.
DR IntAct; P43548; 3.
DR MINT; P43548; -.
DR STRING; 4932.YFL055W; -.
DR TCDB; 2.A.3.10.14; the amino acid-polyamine-organocation (apc) family.
DR iPTMnet; P43548; -.
DR PaxDb; P43548; -.
DR PRIDE; P43548; -.
DR EnsemblFungi; YFL055W_mRNA; YFL055W; YFL055W.
DR GeneID; 850489; -.
DR KEGG; sce:YFL055W; -.
DR SGD; S000001839; AGP3.
DR VEuPathDB; FungiDB:YFL055W; -.
DR eggNOG; KOG1286; Eukaryota.
DR HOGENOM; CLU_007946_12_2_1; -.
DR InParanoid; P43548; -.
DR OMA; WEGGVHL; -.
DR BioCyc; YEAST:G3O-30411-MON; -.
DR SABIO-RK; P43548; -.
DR PRO; PR:P43548; -.
DR Proteomes; UP000002311; Chromosome VI.
DR RNAct; P43548; protein.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IDA:SGD.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR GO; GO:0006865; P:amino acid transport; IDA:SGD.
DR GO; GO:0055085; P:transmembrane transport; IDA:SGD.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR004840; Amoino_acid_permease_CS.
DR Pfam; PF00324; AA_permease; 1.
DR PROSITE; PS00218; AMINO_ACID_PERMEASE_1; 1.
PE 1: Evidence at protein level;
KW Amino-acid transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..558
FT /note="General amino acid permease AGP3"
FT /id="PRO_0000054144"
FT TOPO_DOM 1..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..126
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..168
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..193
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..241
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..280
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 302..324
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 346..375
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 397..402
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 424..446
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 447..467
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 468..480
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 481..501
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 502..558
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 558 AA; 61052 MW; D7AE03BE36ADA1A1 CRC64;
MAVLNLKRET VDIEETAKKD IKPYFASNVE AVDIDEDPDV SRYDPQTGVK RALKNRHISL
LALGGVIGPG CLVGAGNALN KGGPLALLLG FSIIGIIAFS VMESIGEMIT LYPSGGGFTT
LARRFHSDAL PAVCGYAYVV VFFAVLANEY NTLSSILQFW GPQVPLYGYI LIFWFAFEIF
QLVGVGLFGE TEYWLAWLKI VGLVAYYIFS IVYISGDIRN RPAFGFHYWN SPGALSHGFK
GIAIVFVFCS TFYSGTESVA LAATESKNPG KAVPLAVRQT LWRILVVYIG IAVFYGATVP
FDDPNLSAST KVLKSPIAIA ISRAGWAGGA HLVNAFILIT CISAINGSLY IGSRTLTHLA
HEGLAPKILA WTDRRGVPIP AITVFNALGL ISLMNVSVGA ANAYSYIVNL SGVGVFIVWG
VISYTHLRIR KAWVAQGRSI EELPYEALFY PWTPVLSLAA NIFLALIQGW SYFVPFDAGN
FVDAYILLPV GILLYIGICV FKSNHFRTVD LRSINLDEGR RKDMEADLSD QESSLASSET
MKDYKSATFF RYLSNIFT
