ID   ERD12_SCHPO             Reviewed;         387 AA.
AC   Q10151;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Protein ERD1 homolog 2;
GN   ORFNames=SPAC1D4.05c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ERD1 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAA93214.1; -; Genomic_DNA.
DR   PIR; T38046; T38046.
DR   RefSeq; NP_593018.1; NM_001018417.2.
DR   AlphaFoldDB; Q10151; -.
DR   STRING; 4896.SPAC1D4.05c.1; -.
DR   PaxDb; Q10151; -.
DR   PRIDE; Q10151; -.
DR   EnsemblFungi; SPAC1D4.05c.1; SPAC1D4.05c.1:pep; SPAC1D4.05c.
DR   GeneID; 2542527; -.
DR   KEGG; spo:SPAC1D4.05c; -.
DR   PomBase; SPAC1D4.05c; -.
DR   VEuPathDB; FungiDB:SPAC1D4.05c; -.
DR   eggNOG; KOG1162; Eukaryota.
DR   HOGENOM; CLU_024081_2_1_1; -.
DR   InParanoid; Q10151; -.
DR   OMA; VVEFPLH; -.
DR   PhylomeDB; Q10151; -.
DR   PRO; PR:Q10151; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IC:PomBase.
DR   GO; GO:0016021; C:integral component of membrane; ISO:PomBase.
DR   GO; GO:0006621; P:protein retention in ER lumen; ISO:PomBase.
DR   InterPro; IPR004342; EXS_C.
DR   Pfam; PF03124; EXS; 1.
DR   PROSITE; PS51380; EXS; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..387
FT                   /note="Protein ERD1 homolog 2"
FT                   /id="PRO_0000116469"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          212..387
FT                   /note="EXS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00712"
SQ   SEQUENCE   387 AA;  45473 MW;  A21D506EE5232F7D CRC64;
     MDLEVVEFPL HHKLALPFRI GLLVIVGTWL WSVCYHLIYI LNRYQPISPN PRGSLNSKWY
     HLLQIPLSNR HTDLEENTEF KANLVSPVDF HAGYCFAAIL SISWATGFIL FLKKTQGDIG
     GLYSHPIYPL LWVITAFILI VFPFPWRYRS SQRGLRKSII RVFLFFQADF RSPYKDFIVS
     EIFTSYAKAL GDFYIFGCVL QGHISKFTLR PDLKCDGTFF VPLAMAYPFI VAILQCLHYG
     LSRRKHTFKI NLLSALKHAT ALPVIYLSAI IHAKQTKFTL TSGHGYLFWL WILSALLSSA
     YTFLWDVFID WRIRFPFHKS INHKRFPMFI YAIGCFINFI LRVTWSMKLH PRLHQFHEYE
     MGIFSFEMLE ILRRFLWLFF HLDAISS