ID   ERD1_KLULA              Reviewed;         384 AA.
AC   P41771;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Protein ERD1;
GN   Name=ERD1; OrderedLocusNames=KLLA0A02057g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7992512; DOI=10.1002/yea.320100814;
RA   Dean N.;
RT   "Cloning and DNA sequence of a Kluyveromyces lactis ERD1 homologue.";
RL   Yeast 10:1117-1124(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for the retention of luminal endoplasmic reticulum
CC       proteins, affects glycoprotein processing in the Golgi apparatus.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the ERD1 family. {ECO:0000305}.
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DR   EMBL; U04714; AAA21530.1; -; Genomic_DNA.
DR   EMBL; CR382121; CAH02679.1; -; Genomic_DNA.
DR   PIR; S45592; S45592.
DR   RefSeq; XP_451091.1; XM_451091.1.
DR   AlphaFoldDB; P41771; -.
DR   STRING; 28985.XP_451091.1; -.
DR   PRIDE; P41771; -.
DR   EnsemblFungi; CAH02679; CAH02679; KLLA0_A02057g.
DR   GeneID; 2896854; -.
DR   KEGG; kla:KLLA0_A02057g; -.
DR   eggNOG; KOG1162; Eukaryota.
DR   HOGENOM; CLU_765368_0_0_1; -.
DR   InParanoid; P41771; -.
DR   OMA; WIFLRVE; -.
DR   Proteomes; UP000000598; Chromosome A.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR004342; EXS_C.
DR   Pfam; PF03124; EXS; 1.
DR   PROSITE; PS51380; EXS; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..384
FT                   /note="Protein ERD1"
FT                   /id="PRO_0000087008"
FT   TRANSMEM        19..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          189..384
FT                   /note="EXS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00712"
SQ   SEQUENCE   384 AA;  45315 MW;  C064F9A67C96B45B CRC64;
     MDAESVEPFL VYLPIPQRVV VLVLLGLWLW TWFLKVSVSY YDVSKVIVSN ESTGLPYFNT
     STKIHQSSLK LFKSISRVII PWQLVCIILF QYSFTNNVSN KLLWFFLNVS PLLELFYIFA
     MILRSSAMVA RCFKRILWVA DIEPKPYRNN YIIISDTLTS YSKPLVDLAI YATFLFHDPT
     NVKCQVERYE NAISLNIDVL VGVLPSLVRM IQSLREFTRG RSQKKDGSQL FNAFKYAGNI
     PIMLVTVYTR YYNLGPLGMM YWFMFWNSAY SFWWDVTMDW KLELFDFVNG DTSVNNNNSS
     NKADGLLRSI LLYRKNAWYY SAMALDFILR FVWFWEYISG HSVFYGELNI FWLQILEIIR
     RWIWLFFKVE VEYIATTEGG KMDE