ERD21_CAEEL
ID ERD21_CAEEL Reviewed; 213 AA.
AC P48583; O76766;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=ER lumen protein-retaining receptor erd-2.1 {ECO:0000305};
GN Name=erd-2.1 {ECO:0000312|WormBase:F09B9.3};
GN Synonyms=erd-2 {ECO:0000312|WormBase:F09B9.3};
GN ORFNames=F09B9.3 {ECO:0000312|WormBase:F09B9.3};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Banfield D.K., Pelham H.R.B.;
RT "A C. elegans gene encoding a homologue of the ER lumen protein receptor
RT ERD2.";
RL Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Required for the retention of luminal endoplasmic reticulum
CC proteins. Determines the specificity of the luminal ER protein
CC retention system. Also required for normal vesicular traffic through
CC the Golgi (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC membrane protein.
CC -!- SIMILARITY: Belongs to the ERD2 family. {ECO:0000305}.
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DR EMBL; AF081125; AAC31954.1; -; Genomic_DNA.
DR EMBL; BX284606; CAA90056.2; -; Genomic_DNA.
DR PIR; C89623; C89623.
DR PIR; T20636; T20636.
DR RefSeq; NP_509703.1; NM_077302.5.
DR AlphaFoldDB; P48583; -.
DR SMR; P48583; -.
DR STRING; 6239.F09B9.3; -.
DR TCDB; 9.B.191.1.10; the endoplasmic reticulum retention receptor (kdelr) family.
DR PaxDb; P48583; -.
DR EnsemblMetazoa; F09B9.3.1; F09B9.3.1; WBGene00001331.
DR UCSC; F09B9.3; c. elegans.
DR WormBase; F09B9.3; CE23635; WBGene00001331; erd-2.1.
DR eggNOG; KOG3106; Eukaryota.
DR GeneTree; ENSGT00390000004010; -.
DR HOGENOM; CLU_057784_0_0_1; -.
DR InParanoid; P48583; -.
DR OMA; AYTVYLM; -.
DR OrthoDB; 1186269at2759; -.
DR PhylomeDB; P48583; -.
DR Reactome; R-CEL-6807878; COPI-mediated anterograde transport.
DR Reactome; R-CEL-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR PRO; PR:P48583; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00001331; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046923; F:ER retention sequence binding; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0006621; P:protein retention in ER lumen; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR000133; ER_ret_rcpt.
DR PANTHER; PTHR10585; PTHR10585; 1.
DR Pfam; PF00810; ER_lumen_recept; 1.
DR PRINTS; PR00660; ERLUMENR.
DR PROSITE; PS00951; ER_LUMEN_RECEPTOR_1; 1.
DR PROSITE; PS00952; ER_LUMEN_RECEPTOR_2; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; ER-Golgi transport; Membrane; Protein transport;
KW Receptor; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..213
FT /note="ER lumen protein-retaining receptor erd-2.1"
FT /id="PRO_0000194161"
FT TOPO_DOM 1..2
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 3..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 22..35
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..61
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..96
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..117
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..178
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 200..213
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 213 AA; 25060 MW; 9A9D61C99012E48A CRC64;
MNLFRFTADV AHAIAIVVLL LKIWKSRSCE GISGRSQLLF ALVFVTRYLD LFTNFFSFYN
TAMKIFYLVA SFGTVYLMWA KFKATYDRNN DSFRIEFLVI PSMILALLIN HEFIFMEVMW
TFSIYLEAVA IMPQLFMLSR TGNAETITAH YLFALGSYRF LYILNWVYRY YTESFFDPIS
VVAGIVQTVL YADFFYLYIT RVIQSNRQFE MSA
