ERD22_CAEEL
ID ERD22_CAEEL Reviewed; 213 AA.
AC Q09473;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=ER lumen protein-retaining receptor erd-2.2 {ECO:0000305};
GN Name=erd-2.2 {ECO:0000312|WormBase:C28H8.4};
GN ORFNames=C28H8.4 {ECO:0000312|WormBase:C28H8.4};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Required for the retention of luminal endoplasmic reticulum
CC proteins. Determines the specificity of the luminal ER protein
CC retention system. Also required for normal vesicular traffic through
CC the Golgi (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC membrane protein.
CC -!- SIMILARITY: Belongs to the ERD2 family. {ECO:0000305}.
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DR EMBL; BX284603; CCD65964.1; -; Genomic_DNA.
DR PIR; H88469; H88469.
DR RefSeq; NP_498282.1; NM_065881.3.
DR AlphaFoldDB; Q09473; -.
DR SMR; Q09473; -.
DR STRING; 6239.C28H8.4.1; -.
DR PaxDb; Q09473; -.
DR PRIDE; Q09473; -.
DR EnsemblMetazoa; C28H8.4.1; C28H8.4.1; WBGene00016195.
DR EnsemblMetazoa; C28H8.4.2; C28H8.4.2; WBGene00016195.
DR GeneID; 175833; -.
DR KEGG; cel:CELE_C28H8.4; -.
DR UCSC; C28H8.4; c. elegans.
DR CTD; 175833; -.
DR WormBase; C28H8.4; CE01826; WBGene00016195; erd-2.2.
DR eggNOG; KOG3106; Eukaryota.
DR GeneTree; ENSGT00390000004010; -.
DR HOGENOM; CLU_057784_0_0_1; -.
DR InParanoid; Q09473; -.
DR OMA; APFELLW; -.
DR OrthoDB; 1186269at2759; -.
DR PhylomeDB; Q09473; -.
DR Reactome; R-CEL-6807878; COPI-mediated anterograde transport.
DR Reactome; R-CEL-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR PRO; PR:Q09473; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00016195; Expressed in embryo and 4 other tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046923; F:ER retention sequence binding; IEA:InterPro.
DR GO; GO:0006621; P:protein retention in ER lumen; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR InterPro; IPR000133; ER_ret_rcpt.
DR PANTHER; PTHR10585; PTHR10585; 1.
DR Pfam; PF00810; ER_lumen_recept; 1.
DR PRINTS; PR00660; ERLUMENR.
DR PROSITE; PS00951; ER_LUMEN_RECEPTOR_1; 1.
DR PROSITE; PS00952; ER_LUMEN_RECEPTOR_2; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; ER-Golgi transport; Membrane; Protein transport;
KW Receptor; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..213
FT /note="ER lumen protein-retaining receptor erd-2.2"
FT /id="PRO_0000194162"
FT TOPO_DOM 1..2
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 3..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 22..35
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..61
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..96
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..117
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..178
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 200..213
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 213 AA; 24742 MW; 2F6400E38D8D8CF4 CRC64;
MNIFRISADM SHLLAIIILL LKIWKSRSCS GISARSQILF ALVFTARYLD LFSTYISLYN
TTMKITFLAA TYATVYLMFF KFRSTYMRES DTFRVELLIV PAAILALLIN HDFAPFELLW
TFSIYLEAVA ILPQLFLLQS TGSAEVITAH YLFALGSYRA LYIFNWIYRY YTEDYFDPIV
VVAGIVQTVL YADFFYLYVT RVVQTRKGME LPI
