ERD2_PETHY
ID ERD2_PETHY Reviewed; 215 AA.
AC Q9ZTN2;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=ER lumen protein-retaining receptor;
DE AltName: Full=HDEL receptor;
DE AltName: Full=PGP169-12;
GN Name=ERD2;
OS Petunia hybrida (Petunia).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Petunioideae; Petunia.
OX NCBI_TaxID=4102;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10859200; DOI=10.1104/pp.123.2.699;
RA Guyon V.N., Astwood J.D., Garner E.C., Dunker A.K., Taylor L.P.;
RT "Isolation and characterization of cDNAs expressed in the early stages of
RT flavonol-induced pollen germination in petunia.";
RL Plant Physiol. 123:699-710(2000).
CC -!- FUNCTION: Required for the retention of luminal endoplasmic reticulum
CC proteins. Determines the specificity of the luminal ER protein
CC retention system. Also required for normal vesicular traffic through
CC the Golgi. This receptor recognizes H-D-E-L (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC membrane protein.
CC -!- SIMILARITY: Belongs to the ERD2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF049922; AAD02548.1; -; mRNA.
DR AlphaFoldDB; Q9ZTN2; -.
DR SMR; Q9ZTN2; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046923; F:ER retention sequence binding; IEA:InterPro.
DR GO; GO:0006621; P:protein retention in ER lumen; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR InterPro; IPR000133; ER_ret_rcpt.
DR PANTHER; PTHR10585; PTHR10585; 1.
DR Pfam; PF00810; ER_lumen_recept; 1.
DR PRINTS; PR00660; ERLUMENR.
DR PROSITE; PS00951; ER_LUMEN_RECEPTOR_1; 1.
DR PROSITE; PS00952; ER_LUMEN_RECEPTOR_2; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; ER-Golgi transport; Membrane; Protein transport;
KW Receptor; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..215
FT /note="ER lumen protein-retaining receptor"
FT /id="PRO_0000194168"
FT TOPO_DOM 1..2
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 3..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 22..35
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..61
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..98
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..119
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..181
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..215
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 215 AA; 25602 MW; 7A6E4EF4F017CF65 CRC64;
MNIFRLAGDM THLASVLVLL LKIHTIKSCA GVSLKTQELY ALVFVTRYLD IFTDFISLYN
TTMKLVFLGS SLSIVWYMRH HKIVRRSYDK DQDTFRHLFL VLPCLLLALV INEKFTFKEV
MWTFSIYLEA VAILPQLVLL QRTRNIDNLT GQYIFLLGAY RSFYILNWVY RYFTEPHFVH
WITWIAGLIQ TLLYADFFYY YFQSWKNNTK LELPA
